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Machado-Joseph (Azorean) disease in a Yemenite Jewish family in Israel

Department of Neurology, Beilinson Medical Center and Felsenstein Research Center, Petah Tiqva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Machado-Joseph disease (MJD), an autosomal dominant, progressive, multisystem degeneration with cerebellar ataxia as the cardinal manifestation, usually affects individuals of Portuguese ancestry from the Azorean Islands. Cases have been reported in families from Japan, India, China, Brazil, and Australia. We report the first Israeli Jewish family with MJD, originating from a remote village near Ta'izz in Yemen.

Address correspondence and reprint requests to Dr. N. Gadoth, Department of Neurology, Beilinson Medical Center, Petah Tiqva, 49100, Israel.

Received November 16, 1993. Accepted in final form January 11, 1994.

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