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NEUROLOGY 1994;44:1336
© 1994 American Academy of Neurology

Polymerase chain reaction for rapid diagnosis of tuberculous meningitis in AIDS patients

Lola Folgueira, MD, Rafael Delgado, MD, Elia Palenque, MD, PhD and Antonio R. Noriega, MD, PhD

Department of Microbiology, Hospital Doce de Octubre, Madrid, Spain.

We used a test based on the polymerase chain reaction (PCR) for the detection of Mycobacterium tuberculosis DNA in 11 CSF samples from 10 HIV-seropositive patients in whom tuberculous meningitis was suspected. PCR was positive in nine samples from eight patients in whom clinical data, CSF findings, evidence of tuberculosis at an extraneural site, and response to antituberculous drug therapy supported the diagnosis, whereas cultures were positive in five of these nine samples and staining in only one. The PCR was negative in 14 CSF samples from the control group.

Address correspondence and reprint requests to Dr. Lola Folgueira, Centro de Investigación, Hospital Doce de Octubre, Crta. de Andalucía Km. 5,400, 28041 Madrid, Spain.

L. Folgueira is supported by the fellowship BAE 5034/93 from Fondo de Investigación Sanitaria de la Seguridad Social (FIS).

Presented in part at the 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, CA, October 11 to 14, 1992. Abstract number 1634.

Received November 16, 1993. Accepted in final form January 5, 1994




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