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NEUROLOGY 1994;44:1341
© 1994 American Academy of Neurology

Medical intractability in children evaluated for epilepsy surgery

Jamie T. Gilman, PharmD, Michael Duchowny, MD, Prasanna Jayakar, MD, PhD and Trevor J. Resnick, MD

Division of Clinical Pharmacology (Dr. Gilman) and the Department of Neuroscience (Drs. Gilman, Duchowny, Jayakar, and Resnick), Comprehensive Epilepsy Center, Miami Children's Hospital, Miami, FL.

We assessed the value of therapeutic reevaluation and additional pharmacotherapy in medically intractable children referred for epilepsy surgery. In 21 children with antiepileptic drug treatment omissions, correcting the omission was ineffective in 19 (90%). Two children (10%), both of whom had structural lesions, achieved significant seizure control with high-dose carbamazepine monotherapy. Therapeutic reevaluation is indicated in all medically intractable children prior to epilepsy surgery.

Address correspondence and reprint requests to Dr. Jamie Gilman, Clinical Pharmacology and Pharmacokinetics Laboratory, Department of Neuroscience, Miami Children's Hospital, 6125 SW 31st Street, Miami, FL 33155-3098.

Received October 18, 1993. Accepted in final form January 19, 1994.




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