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NEUROLOGY 1994;44:1511
© 1994 American Academy of Neurology

ß2-Adrenergic agonist as adjunct therapy to levodopa in Parkinson's disease

G. M. Alexander, PhD, R. J. Schwartzman, MD, T. A. Nukes, MD, J. R. Grothusen, PhD and M. D. Hooker, MD

Department of Neurology (Drs. Alexander, Schwartzman, Nukes, and Grothusen), Jefferson Medical College, Philadelphia, PA; and the Veterans Administration Hospital (Dr. Hooker), Wilmington, DE.

We studied the effect of the ß2-adrenergic agonist albuterol on Parkinson's disease (PD) patients receiving chronic levodopa treatment. The albuterol-treated patients demonstrated reduced parkinsonian symptoms and an increased ability to tap their index finger between two points 20 cm apart, and were able to perform a "walk test" in 70% of their control time. Three patients currently on chronic albuterol therapy still show amelioration of their parkinsonian symptoms, and two have reduced their daily levodopa dose. This study suggests that ß2-adrenergic agonists as adjunct therapy to levodopa may be beneficial in PD.

Address correspondence and reprint requests to Dr. Guillermo M. Alexander, Department of Neurology, Jefferson Medical College, 1025 Walnut Street, Suite 511, College Building, Philadelphia, PA 19107.

Supported by grant 5 RO1 NS27101 from the National Institutes of Health.

Received September 15, 1993. Accepted in final form February 11, 1994.






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