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NEUROLOGY 1994;44:1521
© 1994 American Academy of Neurology

Anti-Ri antibodies associated with opsoclonus and progressive encephalomyelitis with rigidity

J. L. Casado, MD, A. Gil-Peralta, MD, F. Graus, MD, C. Arenas, MD, J. M. Lopez, MD and R. Alberca, MD

Services of Neurology of the Hospital Universitario Virgen del Rocío (Drs. Casado, Gil-Peralta, Arenas, Lopez, and Alberca), Seville; and the Hospital Clinic (Dr. Graus), Barcelona, Spain.

A 57-year-old woman without a known neoplasia developed opsoclonus, myoclonus, and ataxia. Positive anti-Ri antibodies were present in both serum and CSF. The patient also had progressive encephalomyelitis with rigidity, an association not previously described.

Address correspondence and reprint requests to Dr. Alberto Gil-Peralta, Servicio de Neurologia, Hospital U. Virgen del Rocio, Avda. Manuel Siurot s/n., 41013 Seville, Spain.

Received November 30, 1993. Accepted in final form February 1, 1994.




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