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NEUROLOGY 1995;45:1873-1878
© 1995 American Academy of Neurology

Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurologic disease in mice

Paraneoplastic encephalomyelitis/paraneoplastic sensory neuronopathy (PEM/PSN) associated with small cell lung cancer is characterized by high serum and CSF titers of anti-neuronal (anti-Hu) antibodies and by intrathecal synthesis of anti-Hu IgG. A pathologic role for the anti-Hu antibodies in PEM/PSN is further suggested by reported intraneuronal accumulation of the antibodies in the nervous system of PEM/PSN patients at autopsy. We immunized SJL/J mice, Lewis rats, and Hartley guinea pigs with purified recombinant HuD fusion protein. In spite of high-titer anti-HuD antibodies, neurologic and pathologic examination of the animals was normal. Apparent uptake of purified IgG by neurons in the brain proved to be artifactual.

NEUROLOGY 1995;45: 1873-1878

Presented in part at the 46th annual meeting of the American Academy of Neurology, Washington, DC, May 1994.




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