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NEUROLOGY 1995;45:2199-2202
© 1995 American Academy of Neurology

Sydenham's chorea

Magnetic resonance imaging of the basal ganglia

J.N. Giedd, MD, J.L. Rapoport, MD, M.J.P. Kruesi, MD, C. Parker, MD, M.B. Schapiro, MD, A.J. Allen, MD PhD, H.L. Leonard, MD, D. Kaysen, BS, D.P. Dickstein, BS, W.L. Marsh, BS, P.L. Kozuch, BS, Vaituzis A.C., S.D. Hamburger, MA, MS and S.E. Swedo, MD

From the Child Psychiatry Branch (Drs. Giedd, Rapoport, Kruesi, Allen, Leonard, and Swedo, and D. Kaysen, D.P. Dickstein, W.L. Marsh, P.L. Kozuch, A.C. Vaituzis, and S.D. Hamburger), National Institute of Mental Health; National Institute on Aging (Dr. Schapiro); and National Institute of Neurological Disorders and Stroke (Dr. Parker), National Institutes of Health, Bethesda, MD.
Supported in part by a grant from the Gulton Foundation.
Received November 28, 1994. Accepted in final form March 25, 1995.
Address correspondence and reprint requests to Dr. Jay N. Giedd, National Institutes of Health, NIMH, Child Psychiatry Branch, 9000 Rockville Pike, Building 10, Room 6N240, Bethesda, MD 20892.

Analysis of cerebral magnetic resonance images of 24 subjects with Sydenham's chorea and 48 age-, height-, weight-, gender-, and handedness-matched controls demonstrated increased sizes of the caudate, putamen, and globus pallidus in the Sydenham's chorea group. In contrast, neither total cerebral, prefrontal, or midfrontal volumes or thalamic area were increased. These results indicate the selective involvement of the basal ganglia in Sydenham's chorea.

NEUROLOGY 1995;45: 2199-2203




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