HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lossos, A. Articles by Steiner, I. Search for Related Content PubMed PubMed Citation Articles by Lossos, A. Articles by Steiner, I.

Neurologic Aspects of Inflammatory Bowel Disease

Article abstract-To determine the frequency, spectrum, and clinical features of neurologic disorders associated with ulcerative colitis (UC) and Crohn's disease (CD). Background: Extraintestinal manifestations of inflammatory bowel disease (IBD) are well documented, but the association of IBD with neurologic involvement is rare and often controversial. Methods: Tertiary care center ambulatory and hospital services data bank retrospective computerized search with subsequent file review. Patients: From among 638 IBD patients diagnosed from 1981 to 1991, we identified 10 CD patients and nine UC patients with neurologic involvement unrelated to a defined systemic or iatrogenic cause. Neurologic disorders diagnosed 15 or more years before the intestinal symptomatology were excluded. Results: Three percent of IBD patients had neurologic involvement. In 14 of 19 (74%), it started within a mean of 5.7 years (range, 0.7 to 12 years) after the diagnosis of bowel disease, and in two of 19 (10%) it occurred at the time of IBD exacerbation. During the course of IBD, 10 of 19 patients (53%) exhibited other extraintestinal manifestations. Peripheral nerve disorders were observed in six UC patients. Myelopathy (5 patients), myopathy (3), and myasthenia gravis (1) were diagnosed in eight CD patients and one UC patient. Cerebrovascular disorders occurred in two UC and two CD patients. Conclusions: Neurologic disorders associated with IBD are more common than appreciated and follow a different pattern of involvement in UC and CD. A prospective study is required to define the nature of this association.

NEUROLOGY 1995;45: 416-421

This article has been cited by other articles:

				J. M. Levine, R. L. Bergman, J. R. Coates, and G. D. Shelton Myasthenia Gravis and Hypothyroidism in a Dog With Meningomyelitis J. Am. Anim. Hosp. Assoc., July 1, 2005; 41(4): 247 - 251. [Abstract] [Full Text] [PDF]

				F. A. A. Gondim, T. H. Brannagan III, H. W. Sander, R. L. Chin, and N. Latov Peripheral neuropathy in patients with inflammatory bowel disease Brain, April 1, 2005; 128(4): 867 - 879. [Abstract] [Full Text] [PDF]

				R Foroozan and R Sambursky Ocular myasthenia gravis and inflammatory bowel disease: a case report and literature review Br. J. Ophthalmol., September 1, 2003; 87(9): 1186 - 1187. [Full Text] [PDF]

				R Al-Shahi, C P Warlow, G H Jansen, C. Frijns, and J van Gijn A 59 year old man with progressive spinal cord and peripheral nerve dysfunction culminating in encephalopathy: Edinburgh advanced clinical neurology course, 1999 J. Neurol. Neurosurg. Psychiatry, November 1, 2001; 71(5): 696 - 703. [Full Text] [PDF]

				G D Perkin and I Murray-Lyon Neurology and the gastrointestinal system J. Neurol. Neurosurg. Psychiatry, September 1, 1998; 65(3): 291 - 300. [Full Text]

				A. H. Jackson, G. D. Baquis, and B. L. Shah Congenital Guillain-Barre Syndrome J Child Neurol, September 1, 1996; 11(5): 407 - 410. [PDF]