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NEUROLOGY 1995;45:448-452
© 1995 American Academy of Neurology

Prolactin Secretion Following Repetitive Seizures

D. E. Malkowicz, MD, A. Legido, MD, R. A. Jackel, MD, N. M. Sussman, MD, B. A. Eskin, MD and R. N. Harner, MD

Article abstract-We studied serum prolactin levels after 24 seizures occurring in eight subjects. Video-EEG intracranial monitoring confirmed temporal or frontal partial seizures. Seizure type, focus, and duration were similar for seizures with and without significant postictal prolactin elevations. The seizure-free interval (the time between seizures) varied considerably. Seizures occurring after longer seizure-free intervals (31.75 to 240 hours) showed robust prolactin responses. After shorter seizure-free intervals (1.07 to 25.42 hours), prolactin responses were reduced. This suggests that the amount of releasable prolactin is limited, depleted by seizures, or perhaps inhibited by prolactin feedback. Seizure-free intervals should be considered when interpreting prolactin levels.

NEUROLOGY 1995;45: 448-452




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