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Article abstract-We attempted to define the role of subtle changes in the normal-appearing white matter (NAWM) in the development of disability in multiple sclerosis (MS). Twenty-seven clinically definite MS patients with either relapsing-remitting or chronic-progressive courses and 10 sex- and age-matched controls entered the study. For each patient and control, we studied two NAWM areas in the frontal lobe with magnetization transfer imaging (MTI). For patients, we also calculated the MT ratios (MTRs) for three contiguous areas of NAWM progressively further from "isolated" lesions visible on conventional MRI. Frontal NAWM in MS patients had lower mean MTRs than the frontal white matter of the controls (p = 0.02). MTRs in the NAWM adjacent to isolated lesions increased with distance from them to the cortical gray matter (p = 0.04). This pattern was typical for patients with chronic-progressive MS whose MTRs in the first two regions of NAWM adjacent to lesions were lower than those of the same regions of patients with relapsing-remitting MS. This study confirms that there are alterations in the NAWM of MS patients and suggests that such changes might be relevant to the disability in MS.
NEUROLOGY 1995;45: 478-482
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M Cercignani, M Bozzali, G Iannucci, G Comi, and M Filippi Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis J. Neurol. Neurosurg. Psychiatry, March 1, 2001; 70(3): 311 - 317. [Abstract] [Full Text] [PDF]
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M. Filippi, M. Inglese, M. Rovaris, M. P. Sormani, M. A. Horsfield, G. Iannucci, B. Colombo, and G. Comi Magnetization transfer imaging to monitor the evolution of MS: A 1-year follow-up study Neurology, October 10, 2000; 55(7): 940 - 946. [Abstract] [Full Text] [PDF]
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T L Luks, D E Goodkin, S J Nelson, S Majumdar, P Bacchetti, D Portnoy, and R Sloan A longitudinal study of ventricular volume in early relapsing-remitting multiple sclerosis Multiple Sclerosis, October 1, 2000; 6(5): 332 - 337. [Abstract] [PDF]
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I. Catalaa, R. I. Grossman, D. L. Kolson, J. K. Udupa, L. G. Nyul, L. Wei, X. Zhang, M. Polansky, L. J. Mannon, and J. C. McGowan Multiple Sclerosis: Magnetization Transfer Histogram Analysis of Segmented Normal-appearing White Matter Radiology, August 1, 2000; 216(2): 351 - 355. [Abstract] [Full Text]
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M Filippi, C Tortorella, M Rovaris, M Bozzali, F Possa, M P Sormani, G Iannucci, and G Comi Changes in the normal appearing brain tissue and cognitive impairment in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, February 1, 2000; 68(2): 157 - 161. [Abstract] [Full Text] [PDF]
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M. A. Rocca, B. Colombo, A. Pratesi, G. Comi, and M. Filippi A magnetization transfer imaging study of the brain in patients with migraine Neurology, January 25, 2000; 54(2): 507 - 507. [Abstract] [Full Text] [PDF]
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C. Tortorella, B. Viti, M. Bozzali, M. P. Sormani, G. Rizzo, M. F. Gilardi, G. Comi, and M. Filippi A magnetization transfer histogram study of normal-appearing brain tissue in MS Neurology, January 11, 2000; 54(1): 186 - 186. [Abstract] [Full Text] [PDF]
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U. J. Patel, R. I. Grossman, M. D. Phillips, J. K. Udupa, J. C. McGowan, Y. Miki, L. Wei, M. Polansky, M. A. v. Buchem, and D. Kolson Serial Analysis of Magnetization-Transfer Histograms and Expanded Disability Status Scale Scores in Patients with Relapsing-Remitting Multiple Sclerosis AJNR Am. J. Neuroradiol., November 1, 1999; 20(10): 1946 - 1950. [Abstract] [Full Text]
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S M Leary, N C Silver, V L Stevenson, G J Barker, D H Miller, and A J Thompson Magnetisation transfer of normal appearing white matter in primary progressive multiple sclerosis Multiple Sclerosis, October 1, 1999; 5(5): 313 - 316. [Abstract] [PDF]
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A. Tourbah, J. L. Stievenart, O. Gout, B. Fontaine, R. Liblau, C. Lubetzki, E. A. Cabanis, and O. Lyon-Caen Localized proton magnetic resonance spectroscopy in relapsing remitting versus secondary progressive multiple sclerosis Neurology, September 1, 1999; 53(5): 1091 - 1091. [Abstract] [Full Text]
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S. J. Camp, V. L. Stevenson, A. J. Thompson, D. H. Miller, C. Borras, S. Auriacombe, B. Brochet, M. Falautano, M. Filippi, L. Herisse-Dulo, et al. Cognitive function in primary progressive and transitional progressive multiple sclerosis: A controlled study with MRI correlates Brain, July 1, 1999; 122(7): 1341 - 1348. [Abstract] [Full Text] [PDF]
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L. J. Bagley, R. I. Grossman, S. L. Galetta, G. P. Sinson, M. Kotapka, and J. C. McGowan Characterization of White Matter Lesions in Multiple Sclerosis and Traumatic Brain Injury as Revealed by Magnetization Transfer Contour Plots AJNR Am. J. Neuroradiol., June 1, 1999; 20(6): 977 - 981. [Abstract] [Full Text]
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M. Rocca, Mastronardo, Rodegher, Comi, and Filippi Long-Term Changes of Magnetization Transfer-Derived Measures from Patients with Relapsing-Remitting and Secondary Progressive Multiple AJNR Am. J. Neuroradiol., May 1, 1999; 20(5): 821 - 827. [Abstract] [Full Text]
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G. Pike, de Stefano, Narayanan, G. Francis, J. Antel, and D. Arnold Combined Magnetization Transfer and Proton Spectroscopic Imaging in the Assessment of Pathologic Brain Lesions in Multiple AJNR Am. J. Neuroradiol., May 1, 1999; 20(5): 829 - 837. [Abstract] [Full Text]
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J. Tanabe, Ezekiel, W. Jagust, B. Reed, Norman, Schuff, M. Weiner, Chui, and Fein Magnetization Transfer Ratio of White Matter Hyperintensities in Subcortical Ischemic Vascular AJNR Am. J. Neuroradiol., May 1, 1999; 20(5): 839 - 844. [Abstract] [Full Text]
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C. M. Poser Serial magnetization transfer imaging to characterize the early evolution of new MS lesions Neurology, May 1, 1999; 52(8): 1717 - 1717. [Full Text] [PDF]
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J. L. Ostuni, N. D. Richert, B. K. Lewis, and J. A. Frank Characterization of Differences between Multiple Sclerosis and Normal Brain: A Global Magnetization Transfer Application AJNR Am. J. Neuroradiol., March 1, 1999; 20(3): 501 - 507. [Abstract] [Full Text]
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P. Sarchielli, O. Presciutti, G. P. Pelliccioli, R. Tarducci, G. Gobbi, P. Chiarini, A. Alberti, F. Vicinanza, and V. Gallai Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients Brain, March 1, 1999; 122(3): 513 - 521. [Abstract] [Full Text] [PDF]
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V. L. Stevenson, D. H. Miller, M. Rovaris, F. Barkhof, B. Brochet, V. Dousset, V. Dousset, M. Filippi, X. Montalban, C. H. Polman, et al. Primary and transitional progressive MS: A clinical and MRI cross-sectional study Neurology, March 1, 1999; 52(4): 839 - 839. [Abstract] [Full Text] [PDF]
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M. Filippi, M. A. Rocca, L. Minicucci, V. Martinelli, A. Ghezzi, R. Bergamaschi, and G. Comi Magnetization transfer imaging of patients with definite MS and negative conventional MRI Neurology, March 1, 1999; 52(4): 845 - 845. [Abstract] [Full Text]
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S. G. M. Edwards, Q. Y. Gong, C. Liu, M. E. Zvartau, T. Jaspan, N. Roberts, and L. D. Blumhardt Infratentorial atrophy on magnetic resonance imaging and disability in multiple sclerosis Brain, February 1, 1999; 122(2): 291 - 301. [Abstract] [Full Text] [PDF]
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M. Filippi, G. Iannucci, C. Tortorella, L. Minicucci, M. A. Horsfield, B. Colombo, M. P. Sormani, and G. Comi Comparison of MS clinical phenotypes using conventional and magnetization transfer MRI Neurology, February 1, 1999; 52(3): 588 - 588. [Abstract] [Full Text] [PDF]
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M. Filippi, M. A. Rocca, C. Gasperini, M. P. Sormani, S. Bastianello, M. A. Horsfield, C. Pozzilli, and G. Comi Interscanner Variation in Brain MR Lesion Load Measurements in Multiple Sclerosis Using Conventional Spin-Echo, Rapid Relaxation-Enhanced, and Fast-FLAIR Sequences AJNR Am. J. Neuroradiol., January 1, 1999; 20(1): 133 - 137. [Abstract] [Full Text]
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O. Vladimirova, J. O'Connor, A. Cahill, H. Alder, C. Butunoi, and B. Kalman Oxidative damage to DNA in plaques of MS brains Multiple Sclerosis, October 1, 1998; 4(5): 413 - 418. [Abstract] [PDF]
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 S. J. Khoury and H. L. Weiner Multiple Sclerosis: What Have We Learned From Magnetic Resonance Imaging Studies? Arch Intern Med, March 23, 1998; 158(6): 565 - 573. [Abstract] [Full Text] [PDF]
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A R Massaro and P Tonali Cerebrospinal fluid markers in multiple sclerosis: an overview Multiple Sclerosis, February 1, 1998; 4(1): 1 - 4. [Abstract] [PDF]
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W. Rooney, D. Goodkin, N. Schuff, D. Meyerhoff, D. Norman, and M. Weiner 1H MRSI of normal appearing white matter in multiple sclerosis Multiple Sclerosis, August 1, 1997; 3(4): 231 - 237. [Abstract] [PDF]
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