HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Launer, L. J. Articles by Jonker, C. Search for Related Content PubMed PubMed Citation Articles by Launer, L. J. Articles by Jonker, C.

Medial temporal lobe atrophy in an open population of very old persons

Cognitive, brain atrophy, and sociomedical correlates

Article abstract-Medial temporal lobe structures may be important for memory. We examined the cognitive, brain atrophy, and sociomedical correlates of medial temporal lobe atrophy (MTA) in 59 individuals (79.2 +-\4.6 years old) randomly selected from a population-based study within strata of age and severity of clinically assessed DSM-III-R dementia (45 clinically normal and 14 mild/severely demented). MTA was qualitatively assessed on coronal T₁-weighted MRI. Thirty-three percent of the sample showed MTA, which was associated with dementia severity (p < 0.01), and cortical and white matter atrophy. MTA was not associated with age, education, sex, depressive symptoms, or presence of infarction. Controlling for age, education, and associated brain atrophy, those with MTA performed more poorly on a general test of cognitive function (the neuropsychological test component of the Cambridge Examination for Mental Disorders of the Elderly; p < 0.04) and its subtests of memory function (p < 0.02) and memory-related functions, including perception, fluency, and orientation (p < 0.05). In the clinically normal subsample, those with MTA performed more poorly on the memory function (p < 0.05) subtests. We conclude that MTA is common among very old persons, is associated with other brain abnormalities implicated in cognitive function, but may specifically contribute to memory dysfunction in the general population of very old persons.

NEUROLOGY 1995;45: 747-752

This article has been cited by other articles:

				C. DeCarli, G. B. Frisoni, C. M. Clark, D. Harvey, M. Grundman, R. C. Petersen, L. J. Thal, S. Jin, C. R. Jack Jr, P. Scheltens, et al. Qualitative Estimates of Medial Temporal Atrophy as a Predictor of Progression From Mild Cognitive Impairment to Dementia Arch Neurol, January 1, 2007; 64(1): 108 - 115. [Abstract] [Full Text] [PDF]

				E. S.C. Korf, L. R. White, P. Scheltens, and L. J. Launer Midlife Blood Pressure and the Risk of Hippocampal Atrophy: The Honolulu Asia Aging Study Hypertension, July 1, 2004; 44(1): 29 - 34. [Abstract] [Full Text] [PDF]

				H Hénon, F Pasquier, I Durieu, J P Pruvo, and D Leys Medial temporal lobe atrophy in stroke patients: relation to pre-existing dementia J. Neurol. Neurosurg. Psychiatry, November 1, 1998; 65(5): 641 - 647. [Abstract] [Full Text]

				J. H. Veldink, P. Scheltens, C. Jonker, and L. J. Launer Progression of cerebral white matter hyperintensities on MRI is related to diastolic blood pressure Neurology, July 1, 1998; 51(1): 319 - 320. [Full Text] [PDF]