Neurology, Vol 45, Issue 6 1086-1091, Copyright © 1995 by American Academy of Neurology

ARTICLES

Autosomal dominant migraine with MRI white-matter abnormalities mapping to the CADASIL locus

H Chabriat, E Tournier-Lasserve, K Vahedi, D Leys, A Joutel, A Nibbio, JP Escaillas, MT Iba-Zizen, S Bracard and A Tehindrazanarivelo
Service de Neurologie, Hopital Saint-Antoine, Paris, France.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant cerebral arteriopathy mapped to chromosome 19 and characterized mainly by recurrent subcortical ischemic strokes and extensive white-matter signal abnormalities (WMAs) on magnetic resonance imaging. Other clinical features include migraine attacks and progressive subcortical dementia. Herein, we describe several members of the same family who suffered migraine attacks, mostly with aura, associated with WMAs, segregating with an autosomal dominant pattern of inheritance. One individual had a progressive subcortical dementia with similar WMAs. Although ischemic stroke, one of the hallmarks of CADASIL, was not present in this family, we hypothesized that the present disorder resulted from an alteration of the CADASIL gene. Genetic linkage analysis, using four chromosome 19 markers spanning the CADASIL locus, supports this hypothesis.

This article has been cited by other articles:

				F Schon, R J Martin, M Prevett, C Clough, T P Enevoldson, and H S Markus "CADASIL coma": an underdiagnosed acute encephalopathy J. Neurol. Neurosurg. Psychiatry, February 1, 2003; 74(2): 249 - 252. [Abstract] [Full Text] [PDF]

				I. Le Ber, L. Carluer, N. Derache, C. Lalevee, F. Ledoze, and G. L. Defer Unusual presentation of CADASIL with reversible coma and confusion Neurology, October 8, 2002; 59(7): 1115 - 1116. [Full Text] [PDF]

				M-G BOUSSER and E TOURNIER-LASSERVE Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: from stroke to vessel wall physiology J. Neurol. Neurosurg. Psychiatry, March 1, 2001; 70(3): 285 - 287. [Full Text] [PDF]

				A. Hassan and H. S. Markus Genetics and ischaemic stroke Brain, September 1, 2000; 123(9): 1784 - 1812. [Abstract] [Full Text] [PDF]

				M. Ceroni, T. E. Poloni, S. Tonietti, D. Fabozzi, C. Uggetti, F. Frediani, F. Simonetti, A. Malaspina, D. Alimonti, M. Celano, et al. Migraine with aura and white matter abnormalities: Notch3 mutation Neurology, May 9, 2000; 54(9): 1869 - 1871. [Abstract] [Full Text] [PDF]

				A. Joutel, H. Chabriat, K. Vahedi, V. Domenga, C. Vayssiere, M. M. Ruchoux, C. Lucas, D. Leys, M. G. Bousser, and E. Tournier-Lasserve Splice site mutation causing a seven amino acid Notch3 in-frame deletion in CADASIL Neurology, May 9, 2000; 54(9): 1874 - 1875. [Full Text] [PDF]

				M. VIITANEN and H. KALIMO CADASIL: Hereditary Arteriopathy Leading to Multiple Brain Infarcts and Dementia Ann. N.Y. Acad. Sci., April 1, 2000; 903(1): 273 - 284. [Abstract] [Full Text] [PDF]

				H. Chabriat, S. Pappata, C. Poupon, C. A. Clark, K. Vahedi, F. Poupon, J. F. Mangin, M. Pachot-Clouard, A. Jobert, D. Le Bihan, et al. Clinical Severity in CADASIL Related to Ultrastructural Damage in White Matter : In Vivo Study With Diffusion Tensor MRI Stroke, December 1, 1999; 30(12): 2637 - 2643. [Abstract] [Full Text] [PDF]

				D. W. Desmond, J. T. Moroney, T. Lynch, S. Chan, S. S. Chin, and J. P. Mohr The Natural History of CADASIL : A Pooled Analysis of Previously Published Cases Stroke, June 1, 1999; 30(6): 1230 - 1233. [Abstract] [Full Text] [PDF]

				T. A. Yousry, K. Seelos, M. Mayer, R. Brüning, I. Uttner, M. Dichgans, S. Mammi, A. Straube, N. Mai, and M. Filippi Characteristic MR Lesion Pattern and Correlation of T1 and T2 Lesion Volume with Neurologic and Neuropsychological Findings in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) AJNR Am. J. Neuroradiol., January 1, 1999; 20(1): 91 - 100. [Abstract] [Full Text]