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Neurology, Vol 45, Issue 6 1134-1137, Copyright © 1995 by American Academy of Neurology

ARTICLES

Serum neuron-specific enolase in human status epilepticus

CM DeGiorgio, JD Correale, PS Gott, DL Ginsburg, KA Bracht, T Smith, R Boutros, WJ Loskota and AL Rabinowicz
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033, USA.

Neuron-specific enolase (NSE) is a sensitive marker of brain injury after stroke, global ischemia, and coma. We report changes in serum NSE (s-NSE) in 19 patients who sustained status epilepticus. s-NSE peaked within 24 to 48 hours after status epilepticus. The mean peak s-NSE level for the entire group was elevated compared with the levels for normal controls (24.87 ng/ml versus 5.36 ng/ml, p = 0.0001) and for epileptic controls (24.87 ng/ml versus 4.61 ng/ml, p = 0.0001). The mean peak s-NSE level for the 11 subjects without an acute neurologic insult (15.44 ng/ml) was also significantly increased compared with levels for normal and epileptic controls. Further, s-NSE was significantly correlated with outcome and duration. We conclude that s- NSE is a promising in vivo marker of brain injury in status epilepticus and warrants further study in larger populations.


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