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Neurology, Vol 45, Issue 6 1216-1217, Copyright © 1995 by American Academy of Neurology

ARTICLES

Gabapentin treatment of seizures in acute intermittent porphyria

WO Tatum 4th and SB Zachariah
Department of Neurology, University of South Florida, Tampa, USA.

Most antiepileptic drugs (AEDs) available have demonstrated porphyrogenicity in hepatic porphyrias. Gabapentin is a new AED not appreciably metabolized by the liver in humans. We report two patients with acute intermittent porphyria successfully treated with gabapentin without its inducing porphyric crisis.


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