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NEUROLOGY 1995;45:1216-1217
© 1995 American Academy of Neurology

Gabapentin treatment of seizures in acute intermittent porphyria

William O. Tatum, IV, DO and Sally B. Zachariah, MD

From the Department of Neurology (Drs. Tatum and Zachariah), University of South Florida, Tampa; Tampa General Hospital (Dr. Tatum), Tampa; and the Veterans Administration Medical Center (Dr. Zachariah), Bay Pines, FL.

Article abstract—Most antiepileptic drugs (AEDs) available have demonstrated porphyrogenicity in hepatic porphyrias. Gabapentin is a new AED not appreciably metabolized by the liver in humans. We report two patients with acute intermittent porphyria successfully treated with gabapentin without its inducing porphyric crisis.




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