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From the Department of Neurology (Drs. Tatum and Zachariah), University of South Florida, Tampa; Tampa General Hospital (Dr. Tatum), Tampa; and the Veterans Administration Medical Center (Dr. Zachariah), Bay Pines, FL.
Article abstract—Most antiepileptic drugs (AEDs) available have demonstrated porphyrogenicity in hepatic porphyrias. Gabapentin is a new AED not appreciably metabolized by the liver in humans. We report two patients with acute intermittent porphyria successfully treated with gabapentin without its inducing porphyric crisis.
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