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NEUROLOGY 1995;45:S33-S38
© 1995 American Academy of Neurology

The role of autoimmune T lymphocytes in the pathogenesis of multiple sclerosis

Reinhard Hohlfeld, MD, Edgar Meinl, MD, Frank Weber, MD, Frauke Zipp, MD, Stephan Schmidt, MD, Stefano Sotgiu, MD, Norbert Goebels, MD, Raymond Voltz, MD, Simone Spuler, MD, Antonio Iglesias, PhD and H. Wekerle, MD

From the Department of Neuroimmunology, Max-Planck Institute of Psychiatry, Martinsried, and the Department of Neurology, Klinikum Gro beta hadern, University of Munich, Munich, Germany.
Address correspondence and reprint requests to Professor R. Hohlfeld, Department of Neurology, Klinikum Gro beta hadern, Marchioninistra beta e 15, D-81366 Munich, Germany.

Autoimmune T cells play a key role as regulators and effectors of autoimmune disease.In multiple sclerosis (MS), activated T cells specific for myelin components or other locally expressed autoantigens enter the CNS and recognize their antigen(s) on local antigen-presenting cells. After local stimulation, the T cells produce a plethora of cytokines and inflammatory mediators that have profound effects on the local cellular environment, induce and recruit additional inflammatory cells, and contribute to myelin damage. An increasingly detailed knowledge of these processes will greatly facilitate the development of new immunotherapies. This article focuses on the role of T cells in MS. We provide a brief overview of the principles of T-cell immunology, discuss the experimental techniques available for studying T cells, address the role of T cells in the pathogenesis of MS, and highlight modern concepts for immunotherapy.

NEUROLOGY 1995;45(Suppl 6): S33-S38






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