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Neurology, Vol 45, Issue 7 1384-1391, Copyright © 1995 by American Academy of Neurology

ARTICLES

Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging

G Tedeschi, A Bertolino, A Righini, G Campbell, R Raman, JH Duyn, CT Moonen, JR Alger and G Di Chiro
Neuroimaging Branch, NINDS, NIH, Bethesda, MD 20892, USA.

Proton magnetic resonance spectroscopy (1H-MRS) is evolving from single- volume localized acquisitions to multiple-volume acquisitions using magnetic resonance spectroscopic imaging (1H-MRSI). The normal regional patterns of 1H-MRSI-detectable metabolite signal intensities have yet to be established. We studied 13 healthy young adults with a multiple- section 1H-MRSI technique. The metabolite signals measured were N- acetylaspartate (NA), choline-containing compounds (CHO), creatine- phosphocreatine (CRE), and lactate. Ten neuroanatomic regions (nine bilateral) were identified in gray matter, white matter, and basal nuclei. Analysis of the data led to the following conclusions: (1) NA and CHO signals from centrum semiovale (CSO) can be used as a normalizing factor to reduce intersubject variability due to external causes; (2) in normal human brain, there is no left versus right asymmetry in the regions studied; (3) statistically significant patterns of signal distribution of NA, CHO, and CRE can be identified in normal human brain; and (4) CSO-normalized metabolite signal intensities and metabolite ratios complement each other for the detection of significant regional differences.


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