NEUROLOGY 1996;46:250-251
© 1996 American Academy of Neurology
Reversible encephalopathy with cerebral vasospasm in a Guillain-Barre syndrome patient treated with intravenous immunoglobulin
R. Voltz, MD,
F. V. Rosen, MD,
T. Yousry, MD,
J. Beck and
R. Hohlfeld, MD
From the Department of Neurology (Drs. Voltz, V. Rosen, and Hohlfeld), the Department for Diagnostic Radiology (Dr. Yousry), the Department of Neurosurgery (J. Beck), Klinikum Grobhadern, Munchen, and the Department of Neuroimmunology (Drs. Voltz and Hohlfeld), Max-Planck-Institute, Martinsried, Germany.
Received March 14, 1995. Accepted in final form May 20, 1995.
Address correspondence and reprint requests to Dr. Raymond Voltz, Department of Neurology, Klinikum Grobhadern, 81366 Munchen, Germany.
Article abstract-We report a patient with a reversible multifocal encephalopathy that developed 3 days after completion of treatment with intravenous immunoglobulin for Guillain-Barre syndrome. Magnetic resonance imaging showed reversible bioccipital white matter changes, and transcranial Doppler demonstrated transiently increased flow rates in all major cerebral arteries. We conclude that intravenous immunoglobulin therapy caused cerebral arterial vasospasm and a reversible encephalopathy.
NEUROLOGY 1996;46: 250-251
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