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NEUROLOGY 1996;46:252-254
© 1996 American Academy of Neurology

Cyclosporine-associated mutism in liver transplant patients

F. Valldeoriola, MD, F. Graus, MD, A. Rimola, MD, H. Andreu, MD, J. Santamaria, MD, A. Catafau, MD, J. Visa, MD, E. Tolosa, MD and J. Rodes, MD

From the Service of Neurology (Drs. Valldeoriola, Graus, Santamaria, and Tolosa) and Liver Unit (Drs. Rimola, Andreu, and Rodes), Department of Medicine; Service of Nuclear Medicine (Dr. Catafau), and Service of Surgery (Dr. Visa), Hospital Clinic i Provincial, University of Barcelona, Spain.
Received February 20, 1995. Accepted in final form April 21, 1995.
Address correspondence and reprint requests to Dr. F. Graus, Service of Neurology, Hospital Clinic i Provincial, Villarroel, 170, E-08036-Barcelona, Spain.

Article abstract-Four liver transplant recipients treated with cyclosporine developed a reversible neurologic syndrome characterized by a speech disorder leading to mutism. This complication, previously reported in a few liver transplant recipients treated with the immunosuppressive drug FK506, had not been described with cyclosporine. Recognition of this syndrome should prompt withdrawal of the drug and avoidance of unnecessary diagnostic procedures.

NEUROLOGY 1996;46: 252-254




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F. Bianco, F. Fattapposta, N. Locuratolo, A. Pierallini, M. Rossi, F. Ruberto, and L. Bozzao
Reversible diffusion MRI abnormalities and transient mutism after liver transplantation
Neurology, March 23, 2004; 62(6): 981 - 983.
[Abstract] [Full Text] [PDF]




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