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NEUROLOGY 1996;46:261-263
© 1996 American Academy of Neurology

Melatonin replacement corrects sleep disturbances in a child with pineal tumor

A. Etzioni, MD, R. Luboshitzky, MD, D. Tiosano, MD, M. Ben-Harush, MD, D. Goldsher, MD and P. Lavie, PhD

From the Department of Pediatrics (Drs. Etzioni, Tiosiano, and Ben-Harnsh) and Radiology (Dr. Goldsher), Rambam Medical Center; Department of Endocrinology (Dr. Luboshitzky), Haemek Hospital; and Sleep Laboratory (Dr. Lavie), B. Rappaport School of Medicine, Haifa, Israel.
Received January 23, 1995. Accepted in final form June 5, 1995.
Address correspondence to Dr. Amos Etzioni, Department of Pediatrics, Rambam Medical Center, Haifa, Israel 31096.

Article abstract-A child with a germ cell tumor involving the pineal region had marked suppressed melatonin secretion associated with severe insomnia. Exogenous melatonin (3 mg in the evening) for 2 weeks restored sleep continuity, as demonstrated by objective monitoring of rest-activity cycles. This case report provides direct evidence of the essential role of melatonin in normal sleep.

NEUROLOGY 1996;46: 261-263




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