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NEUROLOGY 1996;46:1029-1035
© 1996 American Academy of Neurology

A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia

R.J. DeLorenzo, MD, PhD, MPH, W. A. Hauser, MD, A. R. Towne, MD, J. G. Boggs, MD, J. M. Pellock, MD, L. Penberthy, MD, L. Garnett, RN, C. A. Fortner and D. Ko, PhD

From the Departments of Neurology (Drs. DeLorenzo, Towne, Boggs, and Pellock, and L. Garnett), Pharmacology and Toxicology (Dr. DeLorenzo), Biochemistry and Molecular Biophysics (Dr. DeLorenzo), Pediatrics (Dr. Pellock), and Biostatistics (Dr. Penberthy, C. Fortner, and Dr. Ko), VCU/MCV Comprehensive Epilepsy Institute, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA; and the Department of Neurology (Dr. Hauser), Columbia University, New York, NY.
Supported by the Medical College of Virginia Epilepsy Research Center (PO2 NS25630) and by the Sophie and Nathan Gumenick Neuroscience and Alzheimer's Research Fund.
Received May 30, 1995. Accepted in final form August 23, 1995.
Address correspondence and reprint requests to Dr. Robert J. DeLorenzo, Department of Neurology, Medical College of Virginia, Virginia Commonwealth University, P.O. Box 980599, Richmond, VA 23298-0599.

This report presents the initial analysis of a prospective, population-based study of status epilepticus (SE) in the city of Richmond, Virginia. The incidence of SE was 41 patients per year per 100,000 population. The frequency of total SE episodes was 50 per year per 100,000 population. The mortality rate for the population was 22%, 3% for children and 26% for adults. Evaluation of the seizure types for adult and pediatric patients demonstrated that both partial and generalized SE occur with a high frequency in these populations. Based on the incidence of SE actually determined in Richmond, Virginia, we project 126,000 to 195,000 SE events with 22,200 to 42,000 deaths per year in the United States. The majority of SE patients had no history of epilepsy. These results indicate that SE is a common neurologic emergency.

NEUROLOGY 1996;46: 1029-1035




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