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Pruritus in Creutzfeldt-Jakob disease

From the Sackler Faculty of Medicine, Tel Aviv University. Tel Aviv, Israel.
Received May 3, 1995. Accepted in final form September 19. 1995.
Address correspondence and reprint requests to Professor A.D. Korczyn, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel.

We report three patients with Creutzfeldt-Jakob disease, whose first symptom was severe pruritus, similar to that observed in scrapie. The pruritus was resistant to therapy. The underlying mechanisms are unclear, but we speculate that the pruritus may result from brainstem involvement.

NEUROLOGY 1996;46: 940-941.

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