Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dooley, J.
Right arrow Articles by Smith, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dooley, J.
Right arrow Articles by Smith, E.
NEUROLOGY 1996;46:969-974
© 1996 American Academy of Neurology

Discontinuation of anticonvulsant therapy in children free of seizures for 1 year

A prospective study

J. Dooley, MB FRCP(C), K. Gordon, MD, MS, FRCP(C), P. Camfield, MD, FRCP(C), C. Camfield, MD, FRCP(C) and E. Smith, RN

From the Department of Pediatrics, Dalhousie University (Drs. Dooley, Gordon, P. Camfield, and C. Camfield), and Neurology Division, IWK Children's Hospital (Drs. Dooley, Gordon, P. Camfield, C. Camfield, and Smith), Halifax, Nova Scotia, Canada.
Received May 18, 1995. Accepted in final form August 30, 1995.
Address correspondence and reprint requests to Dr Dooley, Neurology Division, The IWK Children's Hospital, 5850 University Avenue, Halifax, Nova Scotia, Canada B3J 3G9.

We studied 97 children who were weaned from antiepileptic drug therapy 1 year after their last seizure.Medication was withdrawn over 4 to 8 weeks, and patients were followed for 12 to 57 months (32.4 plus minus 13.1; mean plus minus SD) or until seizure recurrence. The overall probability of remaining seizure free was 78% at 3 months, 71% at 6 months, 66% at 12 months, and 61% at 24 months (95% CI, 51, 71), similar to studies that have required longer treatment periods. Factors retained in multivariate analysis were female sex, age at seizure onset over 120 months of age, seizure type, and clinical evidence of neurologic abnormalities. Using these risk factors, a simple method of predicting the 24-month recurrence risk was possible.

NEUROLOGY 1996;46: 969-974.




This article has been cited by other articles:


Home page
 J Child NeurolHome page
J. G. Serra, M. A. Montenegro, and M. M. Guerreiro
Antiepileptic Drug Withdrawal in Childhood: Does the Duration of Tapering Off Matter for Seizure Recurrence?
J Child Neurol, July 1, 2005; 20(7): 624 - 626.
[Abstract] [PDF]

Home page
 NeurologyHome page
A. T. Geerts, J.M.F. Niermeijer, A. C.B. Peters, W. F.M. Arts, O. F. Brouwer, H. Stroink, E. A.J. Peeters, and C. A. van Donselaar
Four-year outcome after early withdrawal of antiepileptic drugs in childhood epilepsy
Neurology, June 28, 2005; 64(12): 2136 - 2138.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. Camfield and C. Camfield
The frequency of intractable seizures after stopping AEDs in seizure-free children with epilepsy
Neurology, March 22, 2005; 64(6): 973 - 975.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
A. Verrotti, G. di Corcia, C. Salladini, and F. Chiarelli
Discontinuation of Anticonvulsant Therapy and the Electroencephalogram
J Child Neurol, January 1, 2004; 19(1): 81 - 81.
[PDF]

Home page
 J Child NeurolHome page
K. Y. Hawash and N. P. Rosman
Do Partial Seizures Predict an Increased Risk of Seizure Recurrence After Antiepilepsy Drugs Are Withdrawn?
J Child Neurol, May 1, 2003; 18(5): 331 - 337.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
P. Camfield and C. Camfield
Childhood Epilepsy: What Is the Evidence for What We Think and What We Do?
J Child Neurol, April 1, 2003; 18(4): 272 - 287.
[Abstract] [PDF]

Home page
 NeurologyHome page
D. L. Gilbert, G. Sethuraman, U. Kotagal, and C. R. Buncher
Meta-analysis of EEG test performance shows wide variation among studies
Neurology, February 25, 2003; 60(4): 564 - 570.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
J. W. Britton
Antiepileptic Drug Withdrawal: Literature Review
Mayo Clin. Proc., December 1, 2002; 77(12): 1378 - 1388.
[Abstract] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
P A D Bouma, A C B Peters, and O F Brouwer
Long term course of childhood epilepsy following relapse after antiepileptic drug withdrawal
J. Neurol. Neurosurg. Psychiatry, April 1, 2002; 72(4): 507 - 510.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
L M Specchio, L Tramacere, A La Neve, and E Beghi
Discontinuing antiepileptic drugs in patients who are seizure free on monotherapy
J. Neurol. Neurosurg. Psychiatry, January 1, 2002; 72(1): 22 - 25.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
S. Shinnar and J. M. Pellock
Update on the Epidemiology and Prognosis of Pediatric Epilepsy
J Child Neurol, January 1, 2002; 17(1_suppl): S4 - S17.
[Abstract] [PDF]

Home page
 NeurologyHome page
A. Verrotti, S. Morresi, F. Basciani, R. Cutarella, G. Morgese, and F. Chiarelli
Discontinuation of anticonvulsant therapy in children with partial epilepsy
Neurology, November 14, 2000; 55(9): 1393 - 1396.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
D. L. Gilbert and C. R. Buncher
An EEG should not be obtained routinely after first unprovoked seizure in childhood
Neurology, February 8, 2000; 54(3): 635 - 635.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
R. S. Greenwood and M. B. Tennison
When to Start and Stop Anticonvulsant Therapy in Children
Arch Neurol, September 1, 1999; 56(9): 1073 - 1077.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by AAN Enterprises, Inc.