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From the Radiology and Physics Unit (Drs. Gadian and Connelly), the Neurosciences Unit (Drs. Isaacs, Cross, Jackson, Neville, and Vargha-Khadem), the Royal College of Surgeons Unit of Biophysics (Drs. Gadian and King), Institute of Child Health; and the Department of Psychological Medicine (Dr. Vargha-Khadem), Great Ormond Street Hospital for Children, London, UK.
Received May 1, 1995. Accepted in final form August 23, 1995.
Address correspondence and reprint requests to Professor David G. Gadian, Radiology and Physics Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
We used proton magnetic resonance spectroscopy (sup 1 H MRS) for the assessment of focal brain pathology in 22 right-handed children with a diagnosis of intractable temporal lobe epilepsy, and we related this pathology to cognitive dysfunction. Cognitive assessment was based on measurements of verbal IQ, performance IQ, and the Paired Associate Learning subtest of the Wechsler Memory Scale. Five of the 22 children showed no abnormalities of the temporal lobes on1 H MRS, seven showed unilateral pathology, and 10 showed bilateral abnormalities. We found that left-sided pathology is associated with a loss of verbal cognitive functions, whereas right-sided pathology is associated with a loss of nonverbal functions. These findings are consistent with the pattern of lateralization of brain function that has been observed in adults.
NEUROLOGY 1996;46: 974-977.
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