| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Address correspondence and reprint requests to Dr. Mark Hallett, Building 10, Room 5N226, 10 Center Dr MSC 1428, Bethesda, MD 20892-1428.
To assess the excitability of the motor system, we studied 11 patients with task-specific dystonia and 11 age-matched normal subjects. The dominant side was affected in nine of the patients. We delivered transcranial magnetic stimuli at different stimulus intensities and with different levels of muscle facilitation to the side contralateral to the side of electromyographic recording, and recorded motor evoked potentials (MEPs) from the flexor carpi radialis muscles bilaterally. The threshold intensity for eliciting MEPs at rest did not differ between patients and normal subjects. We compared the affected side in patients with the dominant side in normal subjects. With facilitation, the percentage of the area of the MEP to the M wave (MEP area%) was similar in both groups at low stimulus intensities, but with increasing stimulus intensity the increase in the MEP area% was greater in patients than in normal subjects (ANOVA, p <0.001). The increase in MEP area% was similar in both groups with increasing facilitation levels. The duration of the silent period was similar in patients and normal subjects. We conclude that cortical motor excitability is increased in dystonia.
Note. Readers can obtain two pages of supplementary material from the National Auxiliary Publications Service, do Microfiche Publications, PO Box 3513, Grand Central Station, New York, NY 10163-3513. Request document no 05244. Remit with your order (not under separate cover), in US funds only, $7.75 for photocopies or $4.00 for microfiche. Outside the United States and Canada, add postage of $4.50 for the first 20 pages and $1.00 for each 10 pages of material thereafter, or $1.75 for the first microfiche and $50 for each fiche thereafter. There is a $15.00 invoicing charge on all orders filled before payment.
Received August 8, 1995. Accepted in final form February 17, 1995.
This article has been cited by other articles:
|
|
 |
|
  S. Beck, M. Schubert, S. P. Richardson, and M. Hallett Surround inhibition depends on the force exerted and is abnormal in focal hand dystonia J Appl Physiol, November 1, 2009; 107(5): 1513 - 1518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Beck, S. P. Richardson, E. A. Shamim, N. Dang, M. Schubert, and M. Hallett Short Intracortical and Surround Inhibition Are Selectively Reduced during Movement Initiation in Focal Hand Dystonia J. Neurosci., October 8, 2008; 28(41): 10363 - 10369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Dashtipour, M. Barahimi, and S. Karkar Cervical Dystonia Journal of Pharmacy Practice, December 1, 2007; 20(6): 449 - 457. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Dresel, B. Haslinger, F. Castrop, A. M. Wohlschlaeger, and A. O. Ceballos-Baumann Silent event-related fMRI reveals deficient motor and enhanced somatosensory activation in orofacial dystonia Brain, January 1, 2006; 129(1): 36 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Murase, J. C. Rothwell, R. Kaji, R. Urushihara, K. Nakamura, N. Murayama, T. Igasaki, M. Sakata-Igasaki, T. Mima, A. Ikeda, et al. Subthreshold low-frequency repetitive transcranial magnetic stimulation over the premotor cortex modulates writer's cramp Brain, January 1, 2005; 128(1): 104 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Boroojerdi, L. G. Cohen, and M. Hallett Effects of botulinum toxin on motor system excitability in patients with writer's cramp Neurology, December 9, 2003; 61(11): 1546 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Siebner, S. R. Filipovic, J. B. Rowe, C. Cordivari, W. Gerschlager, J. C. Rothwell, R. S. J. Frackowiak, and K. P. Bhatia Patients with focal arm dystonia have increased sensitivity to slow-frequency repetitive TMS of the dorsal premotor cortex Brain, December 1, 2003; 126(12): 2710 - 2725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Schwenkreis, F. Janssen, O. Rommel, B. Pleger, B. Volker, I. Hosbach, R. Dertwinkel, C. Maier, and M. Tegenthoff Bilateral motor cortex disinhibition in complex regional pain syndrome (CRPS) type I of the hand Neurology, August 26, 2003; 61(4): 515 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gilio, A. Curra, M. Inghilleri, C. Lorenzano, A. Suppa, M. Manfredi, and A. Berardelli Abnormalities of motor cortex excitability preceding movement in patients with dystonia Brain, August 1, 2003; 126(8): 1745 - 1754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Nudo Retuning the misfiring brain PNAS, June 24, 2003; 100(13): 7425 - 7427. [Full Text] [PDF]
|
|
|
|
|
|
A. A. Kuhn, B.-U. Meyer, T. Trottenberg, S. A. Brandt, G. H. Schneider, and A. Kupsch Modulation of motor cortex excitability by pallidal stimulation in patients with severe dystonia Neurology, March 11, 2003; 60(5): 768 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Curra, N. Modugno, M. Inghilleri, M. Manfredi, M. Hallett, and A. Berardelli Transcranial magnetic stimulation techniques in clinical investigation Neurology, December 24, 2002; 59(12): 1851 - 1859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tamburin, P. Manganotti, C. A. Marzi, A. Fiaschi, and G. Zanette Abnormal somatotopic arrangement of sensorimotor interactions in dystonic patients Brain, December 1, 2002; 125(12): 2719 - 2730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oga, M. Honda, K. Toma, N. Murase, T. Okada, T. Hanakawa, N. Sawamoto, T. Nagamine, J. Konishi, H. Fukuyama, et al. Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp: an fMRI study Brain, April 1, 2002; 125(4): 895 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Becker, D. Berg, M. Francis, and M. Naumann Evidence for disturbances of copper metabolism in dystonia: From the image towards a new concept Neurology, December 26, 2001; 57(12): 2290 - 2294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Abbruzzese, R. Marchese, A. Buccolieri, B. Gasparetto, and C. Trompetto Abnormalities of sensorimotor integration in focal dystonia: A transcranial magnetic stimulation study Brain, March 1, 2001; 124(3): 537 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Curra, A. Romaniello, A. Berardelli, G. Cruccu, and M. Manfredi Shortened cortical silent period in facial muscles of patients with cranial dystonia Neurology, January 11, 2000; 54(1): 130 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Greenberg, U. Ziemann, G. Cora-Locatelli, A. Harmon, D. L. Murphy, J. C. Keel, and E. M. Wassermann Altered cortical excitability in obsessive-compulsive disorder Neurology, January 11, 2000; 54(1): 142 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rome and R. A. Grunewald Abnormal perception of vibration-induced illusion of movement in dystonia Neurology, November 1, 1999; 53(8): 1794 - 1794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Ibanez, N. Sadato, B. Karp, M.-P. Deiber, and M. Hallett Deficient activation of the motor cortical network in patients with writer's cramp Neurology, July 1, 1999; 53(1): 96 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Feiwell, K. J. Black, L. A. McGee-Minnich, A. Z. Snyder, A.-M. MacLeod, and J. S. Perlmutter Diminished regional cerebral blood flow response to vibration in patients with blepharospasm Neurology, January 1, 1999; 52(2): 291 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hallett The Neurophysiology of Dystonia Arch Neurol, May 1, 1998; 55(5): 601 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Semmler and M. A. Nordstrom Hemispheric Differences in Motor Cortex Excitability During a Simple Index Finger Abduction Task in Humans J Neurophysiol, March 1, 1998; 79(3): 1246 - 1254. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
