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Frequency of MBP and MBP peptide-reactive T cells in the HPRT mutant T-cell population of MS patients

Department of Neurology, Vanderbilt University, Nashville, TN.

Address correspondence and reprint requests to Dr. Patricia A. Lodge, Multiple Sclerosis Research Laboratory, Room 1222, Vanderhilt Stallworth Rehahilitation Hospital, 2201 Capers Ave, Nashville, TN 37212.

Somatic mutation as an index of in vivo T-cell amplification is a powerful tool to analyze the specificity and size of the autoreactive T-cell repertoire. Using this strategy, we determined the precursor frequency of T cells reactive to myelin basic protein (MBP) and overlapping MBP peptides spanning regions p84-168 in patients with MS and controls in the HPRT mutant T-cell population. Among 19 MS patients, nine had estimatable frequencies to MBP or MBP peptides, p93-112, p124-142 and p143-168 in the HPRT mutant T-cell population. Only one of the 10 controls showed measurable frequency to MBP in the HPRT mutant T-cell population. These studies suggest that increased frequency of T cells reactive to MBP and MBP peptides might indicate putative disease-related epitopes in MS.

Received April 28, 1995. Accepted in final form July 12, 1995.

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