| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Clinical Neurosciences (Dr. Salloway), Psychiatry and Human Behavior (Drs. Salloway, Malloy, Kohn, Gillard, Thomas, and Westlake), and Diagnostic Imaging (Drs. Rogg and Tung), Brown University School of Medicine, Providence, RI; the Department of Psychiatry (Dr. Duffy), Medical College of Pennsylvania, Allegheny Branch, Pittsburgh, PA; and the Department of Medicine (Dr. Richardson), Yale University School of Medicine, New Haven, CT.
Received July 13, 1995. Accepted in final form November 2, 1995.
Address correspondence and reprint requests to Dr. Stephen Salloway, Department of Neurology, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906.
We sought to determine whether geriatric patients with late-life-onset major depression have more subcortical hyperintensities on MRI and greater cognitive impairment than age-matched geriatric patients with early-life-onset major depression, suggesting that subcortical disease may be etiologic in late-life depression. Most negative studies of the clinical significance of subcortical hyperintensities on MRI in geriatric patients have sampled from a restricted range of subjects, have employed limited batteries of neuropsychological tests, or have not quantified MRI changes; the present study attempted to address these limitations. Thirty subjects from a geriatric psychiatry inpatient service who were over 60 years of age and presented with major depression were divided into groups with onset of first depression after age 60 (mean = 72.4 years, 15 women, 0 men), and onset of first depression before age 60 (mean = 35.8 years, 12 women, 3 men). Quantitative analysis of MRI yielded the volume of: periventricular hyperintensities (PVH) and deep white-matter hyperintensities (DWMH). Subjects were administered a neuropsychological battery and measures of depression by raters blind to age of onset. The late-onset group had significantly more PVH and DWMH. They were also more impaired on executive and verbal and nonverbal memory tasks. Discriminant function analysis using the severity of subcortical signal hyperintensities on MRI, cognitive index, and depression scores correctly predicted late versus early onset of depression in 87% of the early-onset group and 80% of the late-onset group. These findings suggest that late-life-onset depression may be associated with an increased severity of subcortical vascular disease and greater impairment of cognitive performance.
NEUROLOGY 1996;46: 1567-1574
This article has been cited by other articles:
|
|
 |
|
  L. Saba, R. Sanfilippo, L. Pascalis, R. Montisci, and G. Mallarini Carotid Artery Abnormalities and Leukoaraiosis in Elderly Patients: Evaluation with MDCT Am. J. Roentgenol., February 1, 2009; 192(2): W63 - W70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Blazer Depression in Late Life: Review and Commentary Focus, January 1, 2009; 7(1): 118 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L L Herrmann, M Le Masurier, and K P Ebmeier White matter hyperintensities in late life depression: a systematic review J. Neurol. Neurosurg. Psychiatry, June 1, 2008; 79(6): 619 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Jorge, D. J. Moser, L. Acion, and R. G. Robinson Treatment of Vascular Depression Using Repetitive Transcranial Magnetic Stimulation Arch Gen Psychiatry, March 1, 2008; 65(3): 268 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ballmaier, K. L. Narr, A. W. Toga, V. Elderkin-Thompson, P. M. Thompson, L. Hamilton, E. Haroon, D. Pham, A. Heinz, and A. Kumar Hippocampal Morphology and Distinguishing Late-Onset From Early-Onset Elderly Depression Am J Psychiatry, February 1, 2008; 165(2): 229 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Janssen, H. E Hulshoff Pol, F.-E. de Leeuw, H. G Schnack, I. K Lampe, R. M Kok, R. S Kahn, and T. J Heeren Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early and late onset depression J. Neurol. Neurosurg. Psychiatry, June 1, 2007; 78(6): 638 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kado, H. Kimura, T. Murata, K. Nagata, and I. Kanno Depressive Psychosis: Clinical Usefulness of MR Spectroscopy Data in Predicting Prognosis Radiology, January 1, 2006; 238(1): 248 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. D. Taylor, D. C. Steffens, M. E. Payne, J. R. MacFall, D. A. Marchuk, I. K. Svenson, and K. R. R. Krishnan Influence of Serotonin Transporter Promoter Region Polymorphisms on Hippocampal Volumes in Late-Life Depression Arch Gen Psychiatry, May 1, 2005; 62(5): 537 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Elias, M. F. Elias, R. B. D'Agostino, L. M. Sullivan, and P. A. Wolf Serum Cholesterol and Cognitive Performance in the Framingham Heart Study Psychosom Med, January 1, 2005; 67(1): 24 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ballmaier, A. Kumar, P. M. Thompson, K. L. Narr, H. Lavretsky, L. Estanol, H. DeLuca, and A. W. Toga Localizing Gray Matter Deficits in Late-Onset Depression Using Computational Cortical Pattern Matching Methods Am J Psychiatry, November 1, 2004; 161(11): 2091 - 2099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Artero, H Tiemeier, N D Prins, R Sabatier, M M B Breteler, and K Ritchie Neuroanatomical localisation and clinical correlates of white matter lesions in the elderly J. Neurol. Neurosurg. Psychiatry, September 1, 2004; 75(9): 1304 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R A Kenny, F E Shaw, J T O'Brien, P H Scheltens, R Kalaria, and C Ballard Carotid sinus syndrome is common in dementia with Lewy bodies and correlates with deep white matter lesions J. Neurol. Neurosurg. Psychiatry, July 1, 2004; 75(7): 966 - 971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Butters, E. M. Whyte, R. D. Nebes, A. E. Begley, M. A. Dew, B. H. Mulsant, M. D. Zmuda, R. Bhalla, C. C. Meltzer, B. G. Pollock, et al. The Nature and Determinants of Neuropsychological Functioning in Late-Life Depression Arch Gen Psychiatry, June 1, 2004; 61(6): 587 - 595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Lloyd, I. N. Ferrier, R. Barber, A. Gholkar, A. H. Young, and J. T. O'brien Hippocampal volume change in depression: late- and early-onset illness compared The British Journal of Psychiatry, June 1, 2004; 184(6): 488 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Blazer Depression in Late Life: Review and Commentary J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2003; 58(3): M249 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. BALDWIN and J. O'BRIEN Vascular basis of late-onset depressive disorder The British Journal of Psychiatry, February 1, 2002; 180(2): 157 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. de Groot, F.-E. de Leeuw, M. Oudkerk, A. Hofman, J. Jolles, and M. M. B. Breteler Cerebral White Matter Lesions and Depressive Symptoms in Elderly Adults Arch Gen Psychiatry, November 1, 2000; 57(11): 1071 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Briley, S. Haroon, S. M. Sergent, and S. Thomas Does leukoaraiosis predict morbidity and mortality? Neurology, January 11, 2000; 54(1): 90 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Narayan, J. D. Bremner, and A. Kumar Neuroanatomic Substrates of Late-Life Mental Disorders J Geriatr Psychiatry Neurol, October 1, 1999; 12(3): 95 - 106. [Abstract] [PDF]
|
|
|
|
|
|
R Barber, P Scheltens, A Gholkar, C Ballard, I McKeith, P Ince, R Perry, and J O'Brien White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging J. Neurol. Neurosurg. Psychiatry, July 1, 1999; 67(1): 66 - 72. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. H. Salat, J. A. Kaye, and J. S. Janowsky Prefrontal Gray and White Matter Volumes in Healthy Aging and Alzheimer Disease Arch Neurol, March 1, 1999; 56(3): 338 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B S Everitt and S Landau The use of multivariate statistical methods in psychiatry Statistical Methods in Medical Research, June 1, 1998; 7(3): 253 - 277. [Abstract] [PDF]
|
|
|
|
 |
|
 R. M. Lane SSRI-Induced extrapyramidal side-effects and akathisia: implications for treatment J Psychopharmacol, January 1, 1998; 12(2): 192 - 214. [Abstract] [PDF]
|
|
|
|
|
|
J. D. Amsterdam Selective serotonin reuptake inhibitor efficacy in severe and melancholic depression J Psychopharmacol, January 1, 1998; 12(4_suppl): S99 - S111. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Suzuki, A. Wada, Y. Isaka, K. Maki, T. Inoue, and Y. Fukuhara Cerebral Magnetic Resonance T2 High Intensities in End-Stage Renal Disease Stroke, December 1, 1997; 28(12): 2528 - 2531. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
