| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Wien Center for Alzheimer's Disease and Memory Disorders (Drs. Duara and Loewenstein, Mr. Barker, Lopez-Alberola, Gilchrist, and Ms. Grau), Mount Sinai Medical Center, Miami Beach, FL; Departments of Medicine and Neurology (Dr. Duara) and Psychiatry (Drs. Duara, Loewenstein, and Sevush), University of Miami School of Medicine, Miami, FL; and Division of Neurology, Departments of Medicine and Physiology (Dr. St. George-Hyslop), Center for Research in Neuro-degenerative Diseases, University of Toronto, Toronto, Canada.
Supported partially under an agreement with the Department of Elder Affairs of the State of Florida.
Received February 27, 1995. Accepted in final form October 18, 1995.
Address correspondence and reprint requests to Dr. Ranjan Duara, Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center; 4300 Alton Road; Miami Beach, FL 33140.
We evaluated 197 patients with predominantly late-onset Alzheimer's disease (AD) who belonged to several ethnic groups and analyzed the relationship of age of onset of AD to the presence or absence of several risk factors in this entire group of patients. The apolipoprotein E (apoE) epsilon 4 allele frequency, which was 29% in all patients (compared with the reported population mean of 13.7%, p < 0.001, did not vary significantly between ethnic groups but declined significantly with increasing age. The apoE epsilon 2 allele frequency was 3%, compared with the reported population mean of 7.4% (p = 0.001). The frequency of a positive family history of dementia in first-degree relatives (FH+) (overall 45%) did not vary significantly between ethnic groups. ApoE epsilon 4-positive (epsilon 4+) patients tended to have a higher FH+ rate (58%) than apoE epsilon 4-negative (epsilon 4-) patients (40%) (p = 0.02). When the potential risk factors of gender, education, FH+ status, and epsilon 4+ status were examined together in a multiple linear-regression analysis, FH+ and epsilon 4+ status (but not gender or education) were significant (they were both associated with an earlier age of onset of AD). In a post-hoc analysis, we found a reduced age of onset in women, but not men, who were both FH+ and epsilon 4+. Additionally, those probands who were epsilon 4+ were more likely to inherit the disease from their mothers than their fathers. The mechanism by which epsilon 4+ and FH+ status operate as risk factors may be by their effect on the age of onset of AD.
NEUROLOGY 1996;46: 1575-1579
This article has been cited by other articles:
|
|
 |
|
  E. Gomez-Tortosa, M. S. Barquero, M. Baron, M. J. Sainz, S. Manzano, M. Payno, R. Ros, C. Almaraz, P. Gomez-Garre, and A. Jimenez-Escrig Variability of Age at Onset in Siblings With Familial Alzheimer Disease Arch Neurol, December 1, 2007; 64(12): 1743 - 1748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Olarte, N. Schupf, J. H. Lee, M.-X. Tang, V. Santana, J. Williamson, P. Maramreddy, B. Tycko, and R. Mayeux Apolipoprotein E {varepsilon}4 and Age at Onset of Sporadic and Familial Alzheimer Disease in Caribbean Hispanics Arch Neurol, November 1, 2006; 63(11): 1586 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Clark, C. DeCarli, D. Mungas, H. I. Chui, R. Higdon, J. Nunez, H. Fernandez, M. Negron, J. Manly, S. Ferris, et al. Earlier Onset of Alzheimer Disease Symptoms in Latino Individuals Compared With Anglo Individuals Arch Neurol, May 1, 2005; 62(5): 774 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Huang, C. Qiu, E. von Strauss, B. Winblad, and L. Fratiglioni APOE Genotype, Family History of Dementia, and Alzheimer Disease Risk: A 6-Year Follow-up Study Arch Neurol, December 1, 2004; 61(12): 1930 - 1934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Ercoli, P. Siddarth, J. J. Dunkin, J. Bramen, and G. W. Small MMSE Items Predict Cognitive Decline in Persons with Genetic Risk for Alzheimer's Disease J Geriatr Psychiatry Neurol, June 1, 2003; 16(2): 67 - 73. [Abstract] [PDF]
|
|
|
|
|
|
R. C. Green, L. A. Cupples, A. Kurz, S. Auerbach, R. Go, D. Sadovnick, R. Duara, W. A. Kukull, H. Chui, T. Edeki, et al. Depression as a Risk Factor for Alzheimer Disease: The MIRAGE Study Arch Neurol, May 1, 2003; 60(5): 753 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Dal Forno, K. A. Carson, R. Brookmeyer, J. Troncoso, C. H. Kawas, and J. Brandt APOE genotype and survival in men and women with Alzheimer's disease Neurology, April 9, 2002; 58(7): 1045 - 1050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Graff-Radford, R. C. Green, R. C. P. Go, M. L. Hutton, T. Edeki, D. Bachman, J. L. Adamson, P. Griffith, F. B. Willis, M. Williams, et al. Association Between Apolipoprotein E Genotype and Alzheimer Disease in African American Subjects Arch Neurol, April 1, 2002; 59(4): 594 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Romas, V. Santana, J. Williamson, A. Ciappa, J. H. Lee, H. Z. Rondon, P. Estevez, R. Lantigua, M. Medrano, M. Torres, et al. Familial Alzheimer Disease Among Caribbean Hispanics: A Reexamination of Its Association With APOE Arch Neurol, January 1, 2002; 59(1): 87 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.C. Goldstein, A.V. Ashley, M. Gearing, J. Hanfelt, L. Penix, L.J. Freedman, and A.I. Levey Apolipoprotein E and age at onset of Alzheimer's disease in African American patients Neurology, November 27, 2001; 57(10): 1923 - 1925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ghebremedhin, C. Schultz, D.R. Thal, U. Rub, T.G. Ohm, E. Braak, and H. Braak Gender and age modify the association between APOE and AD-related neuropathology Neurology, June 26, 2001; 56(12): 1696 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Harwood, W. W. Barker, R. L. Ownby, M. J. Mullan, and R. Duara Family History of Dementia and Current Depression in Nondemented Community-Dwelling Older Adults J Geriatr Psychiatry Neurol, July 1, 2000; 13(2): 65 - 71. [Abstract] [PDF]
|
|
|
|
 |
|
 S P McIlroy, V L S Crawford, K B Dynan, B M McGleenon, M D Vahidassr, J T Lawson, and A P Passmore Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland J. Med. Genet., March 1, 2000; 37(3): 182 - 185. [Abstract] [Full Text]
|
|
|
|
|
|
D. C. Steffens, B. L. Plassman, M. J. Helms, K. A. Welsh-Bohmer, T. T. Newman, and J. C. S. Breitner APOE and AD concordance in twin pairs as predictors of AD in first-degree relatives Neurology, February 8, 2000; 54(3): 593 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Del Ser, V. Hachinski, H. Merskey, and D. G. Munoz An autopsy-verified study of the effect of education on degenerative dementia Brain, December 1, 1999; 122(12): 2309 - 2319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Farlow, P. A. Cyrus, A. Nadel, D. K. Lahiri, A. Brashear, and B. Gulanski Metrifonate treatment of AD: Influence of APOE genotype Neurology, December 1, 1999; 53(9): 2010 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Smith, A. H. Andersen, R. J. Kryscio, F. A. Schmitt, M. S. Kindy, L. X. Blonder, and M. J. Avison Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease Neurology, October 22, 1999; 53(7): 1391 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Lerner Alzheimer's Disease in Males: Endocrine Issues and Prospects J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3416 - 3419. [Full Text] [PDF]
|
|
|
|
|
|
G. Devi, R. Ottman, M. Tang, K. Marder, Y. Stern, B. Tycko, and R. Mayeux Influence of APOE genotype on familial aggregation of AD in an urban population Neurology, September 1, 1999; 53(4): 789 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Lerner Women and Alzheimer's Disease J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 1830 - 1834. [Full Text]
|
|
|
|
|
|
D. G. Harwood, W. W. Barker, D. A. Loewenstein, R. L. Ownby, P. St. George-Hyslop, M. Mullan, and R. Duara A cross-ethnic analysis of risk factors for AD in white Hispanics and white non-Hispanics Neurology, February 1, 1999; 52(3): 551 - 551. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Gao, H. C. Hendrie, K. S. Hall, and S. Hui The Relationships Between Age, Sex, and the Incidence of Dementia and Alzheimer Disease: A Meta-analysis Arch Gen Psychiatry, September 1, 1998; 55(9): 809 - 815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V Bowler, D. G Munoz, H. Merskey, and V. Hachinski Factors affecting the age of onset and rate of progression of Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, August 1, 1998; 65(2): 184 - 190. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. A. Farrer, L. A. Cupples, J. L. Haines, B. Hyman, W. A. Kukull, R. Mayeux, R. H. Myers, M. A. Pericak-Vance, N. Risch, and C. M. van Duijn Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis JAMA, October 22, 1997; 278(16): 1349 - 1356. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
