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NEUROLOGY 1996;46:1599-1603
© 1996 American Academy of Neurology

Reversible dementia and chorea in a young woman with the lupus anticoagulant

Gage Van Horn, MD, Frank C. Arnett, MD and Mazen M. Dimachkie, MD

From the Departments of Neurology (Drs. Van Horn and Dimachkie) and Internal Medicine and Pathology and Laboratory Medicine (Dr. Arnett), University of Texas Health Science Center at Houston (Medical School), Houston, TX.
Received August 23, 1995. Accepted in final form November 15, 1995.
Address correspondence and reprint requests to Dr. Gage Van Horn, 6431 Fannin # 7.044, Houston, TX 77030.

A 22-year-old woman gradually developed depression, dementia, and chorea over an 8-month period. She fulfilled the criteria for the primary antiphospholipid antibody syndrome but not those for systemic lupus erythematosus. Her chorea and neurobehavioral deficits responded favorably to a regimen of prednisone, hydroxychloroquine, and aspirin. This appears to be the first report of a patient with a lupus anticoagulant and reversible dementia. The response to immunosuppressive therapy implies an antibody-mediated condition similar to Sydenham's chorea.

NEUROLOGY 1996;46: 1599-1603




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