| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From The University of Texas M.D. Anderson Cancer Center (Drs. Moore, Slopis, Schomer, and Jackson and B. Levy), Houston, and The University of Texas Medical School at Houston (Dr. Slopis), Houston, TX.
Supported by grants from the Texas Neurofibromatosis Foundation, the John P. McGovern Fund for Behavioral Sciences, and the T.L.L. Temple Foundation.
Received February 27, 1995. Accepted in final form October 9, 1995.
Address correspondence and reprint requests to Dr. Bartlett D. Moore III, Division of Pediatrics (Box 87), U.T. M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030.
Of children with neurofibromatosis (NF), 40% have a cognitive or learning impairment.Approximately 60% also have anomalous areas of high signal intensity on T2-weighted brain MRIs. The association of these hyperintensities and neuropsychological status is not fully understood. We administered a battery of neuropsychological tests and a standard clinical MRI to determine the impact of hyperintensity presence, number, and location on cognitive status in 84 children (8 to 16 years) with NF type 1. These children underwent standard clinical MRI using a GE 1.5-tesla scanner (except one child who was examined with a 1.0-tesla scanner). We conducted three types of analyses: Hyperintensity presence or absence.--Scores of children with (55%) and without hyperintensities (45%) were compared using t tests. No statistically significant differences between groups in intellectual functioning or any neuropsychological variable were found. Number of hyperintensities--The number of hyperintensity locations per child ranged from one to five (mean = 2.22). Pearson correlations revealed no significant association between the number of hyperintensities and neuropsychological performance. Location of hyperintensities--In four of the five locations studied, no statistically significant differences were found between scores of children with a hyperintensity in an area and those with one elsewhere. However, mean scores for IQ, Memory, Motor, Distractibility, and Attention domains for children with hyperintensities in the thalamus were significantly lower than scores for those with hyperintensities elsewhere. These results suggest that the simple presence or absence of hyperintensities, or their total number, is not as important as their anatomic location for detecting their relationship with neuropsychological status. Taking location into account, hyperintensities in the cerebral hemispheres, basal ganglia, brainstem, or cerebellum seem to have no impact on neuropsychological functioning, whereas hyperintensities in the thalamus do.
NEUROLOGY 1996;46: 1660-1668
This article has been cited by other articles:
|
|
 |
|
  S. L Hyman, D. S Gill, E. A. Shores, A. Steinberg, and K. N North T2 hyperintensities in children with neurofibromatosis type 1 and their relationship to cognitive functioning J. Neurol. Neurosurg. Psychiatry, October 1, 2007; 78(10): 1088 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.L. Zamboni, T. Loenneker, E. Boltshauser, E. Martin, and K.A. Il'yasov Contribution of Diffusion Tensor MR Imaging in Detecting Cerebral Microstructural Changes in Adults with Neurofibromatosis Type 1 AJNR Am. J. Neuroradiol., April 1, 2007; 28(4): 773 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. S. Goh, P.-L. Khong, C. S. Y. Leung, and V. C. N. Wong T 2-Weighted Hyperintensities (Unidentified Bright Objects) in Children With Neurofibromatosis 1: Their Impact on Cognitive Function J Child Neurol, November 1, 2004; 19(11): 853 - 858. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Feldmann, J. Denecke, M. Grenzebach, G. Schuierer, and J. Weglage Neurofibromatosis type 1: Motor and cognitive function and T2-weighted MRI hyperintensities Neurology, December 23, 2003; 61(12): 1725 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Billingsley, E. F. Jackson, J. M. Slopis, P. R. Swank, S. Mahankali, and B. D. Moore Functional Magnetic Resonance Imaging of Phonologic Processing in Neurofibromatosis 1 J Child Neurol, November 1, 2003; 18(11): 731 - 740. [Abstract] [PDF]
|
|
|
|
|
|
A. G. Lasker, M. B. Denckla, and D. S. Zee Ocular Motor Behavior of Children With Neurofibromatosis 1 J Child Neurol, May 1, 2003; 18(5): 348 - 355. [Abstract] [PDF]
|
|
|
|
|
|
S.L. Hyman, D.S. Gill, E.A. Shores, A. Steinberg, P. Joy, S.V. Gibikote, and K.N. North Natural history of cognitive deficits and their relationship to MRI T2-hyperintensities in NF1 Neurology, April 8, 2003; 60(7): 1139 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Korf Review Article : Clinical Features and Pathobiology of Neurofibromatosis 1 J Child Neurol, August 1, 2002; 17(8): 573 - 577. [Abstract] [PDF]
|
|
|
|
|
|
D. H. Gutmann Review Article : Neurofibromin in the Brain J Child Neurol, August 1, 2002; 17(8): 592 - 601. [Abstract] [PDF]
|
|
|
|
|
|
K. North, S. Hyman, and B. Barton Review Article : Cognitive Deficits in Neurofibromatosis 1 J Child Neurol, August 1, 2002; 17(8): 605 - 612. [Abstract] [PDF]
|
|
|
|
 |
|
 R. L. Billingsley, G. W. Schrimsher, E. F. Jackson, J. M. Slopis, and B. D. Moore III Significance of Planum Temporale and Planum Parietale Morphologic Features in Neurofibromatosis Type 1 Arch Neurol, April 1, 2002; 59(4): 616 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Steen, J. S. Taylor, J. W. Langston, J. O. Glass, V. R. Brewer, W. E. Reddick, R. Mages, and E. K. Pivnick Prospective Evaluation of the Brain in Asymptomatic Children with Neurofibromatosis Type 1: Relationship of Macrocephaly to T1 Relaxation Changes and Structural Brain Abnormalities AJNR Am. J. Neuroradiol., May 1, 2001; 22(5): 810 - 817. [Abstract] [Full Text]
|
|
|
|
|
|
L. E. Cutting, C. W. Koth, C. P. Burnette, M. T. Abrams, W. E. Kaufmann, and M. Bridge Denckla Relationship of Cognitive Functioning, Whole Brain Volumes, and T2-Weighted Hyperintensities in Neurofibromatosis-1 J Child Neurol, March 1, 2000; 15(3): 157 - 160. [Abstract] [PDF]
|
|
|
|
|
|
B. D. Moore III, J. M. Slopis, E. F. Jackson, A. E. De Winter, and N. E. Leeds Brain volume in children with neurofibromatosis type 1: Relation to neuropsychological status Neurology, February 22, 2000; 54(4): 914 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Kayl, B. D. Moore, J. M. Slopis, E. F. Jackson, and N. E. Leeds Quantitative Morphology of the Corpus Callosum in Children With Neurofibromatosis and Attention-Deficit Hyperactivity Disorder J Child Neurol, February 1, 2000; 15(2): 90 - 96. [Abstract] [PDF]
|
|
|
|
|
|
D. H. Gutmann Learning Disabilities in Neurofibromatosis 1: Sizing Up the Brain Arch Neurol, November 1, 1999; 56(11): 1322 - 1323. [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. De Winter, B. D. Moore III, J. M. Slopis, J. L. Ater, and D. R. Copeland Brain tumors in children with neurofibromatosis: Additional neuropsychological morbidity? Neuro-oncol, October 1, 1999; 1(4): 275 - 281. [Abstract] [PDF]
|
|
|
|
|
|
O. Gonen, Z. J. Wang, A. K. Viswanathan, P. T. Molloy, and R. A. Zimmerman Three-Dimensional Multivoxel Proton MR Spectroscopy of the Brain in Children with Neurofibromatosis Type 1 AJNR Am. J. Neuroradiol., August 1, 1999; 20(7): 1333 - 1341. [Abstract] [Full Text]
|
|
|
|
|
|
D. H. Gutmann Recent Insights Into Neurofibromatosis Type 1: Clear Genetic Progress Arch Neurol, June 1, 1998; 55(6): 778 - 780. [Full Text] [PDF]
|
|
|
|
|
|
A. M. Kaplan, K. Chen, M. A. Lawson, D. L. Wodrich, C. T. Bonstelle, and E. M. Reiman Positron Emission Tomography in Children With Neurofibromatosis-1 J Child Neurol, November 1, 1997; 12(8): 499 - 506. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
