HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Castellani, R. Articles by Gambetti, P. Search for Related Content PubMed PubMed Citation Articles by Castellani, R. Articles by Gambetti, P.

Early pathologic and biochemical changes in Creutzfeldt-Jakob disease

Study of brain biopsies

From the Division of Neuropathology, Institute of Pathology (Drs. Castellani, Parchi, Capellari, Cohen, and Gambetti) and Department of Neurology (Dr. Stahl), Case Western Reserve University, Cleveland, OH.
Supported in part by National Institutes of Health grants AG08012, AG08155, and AG08992, and the Britton Fund.
Received August 4, 1995. Accepted in final form October 31, 1995.
Address correspondence and reprint requests to Dr. R. Castellani, Institute of Pathology (Division of Neuropathology), 2085 Adelbert Road, Cleveland, OH 44106.

We examined brain biopsy tissue from five patients with a neurologic syndrome consistent with Creutzfeldt-Jakob disease using Western blot analysis and immunohistochemistry for the detection of protease-resistant prion protein, in addition to histopathologic examination. Our results indicate that the formation of protease-resistant prion protein is an early event in disease pathogenesis and Western blot analysis can detect protease-resistant prion protein in the absence of structural lesions using a small amount of brain biopsy tissue.

NEUROLOGY 1996;46: 1690-1693

This article has been cited by other articles:

				H. Furukawa, K. Doh-ura, R. Okuwaki, S. Shirabe, K. Yamamoto, H. Udono, T. Ito, S. Katamine, and M. Niwa A Pitfall in Diagnosis of Human Prion Diseases Using Detection of Protease-resistant Prion Protein in Urine: CONTAMINATION WITH BACTERIAL OUTER MEMBRANE PROTEINS J. Biol. Chem., May 28, 2004; 279(22): 23661 - 23667. [Abstract] [Full Text] [PDF]

				C. Casalone, G. Zanusso, P. Acutis, S. Ferrari, L. Capucci, F. Tagliavini, S. Monaco, and M. Caramelli Identification of a second bovine amyloidotic spongiform encephalopathy: Molecular similarities with sporadic Creutzfeldt-Jakob disease PNAS, March 2, 2004; 101(9): 3065 - 3070. [Abstract] [Full Text] [PDF]

				C. A. Rentz Creutzfeldt-Jakob disease: Two case studies American Journal of Alzheimer's Disease and Other Dementias, May 1, 2003; 18(3): 171 - 180. [Abstract] [PDF]

				G. Zanusso, S. Ferrari, F. Cardone, P. Zampieri, M. Gelati, M. Fiorini, A. Farinazzo, M. Gardiman, T. Cavallaro, M. Bentivoglio, et al. Detection of Pathologic Prion Protein in the Olfactory Epithelium in Sporadic Creutzfeldt-Jakob Disease N. Engl. J. Med., February 20, 2003; 348(8): 711 - 719. [Abstract] [Full Text] [PDF]

				B. B. Worrall, L. P. Rowland, S. S.-M. Chin, and J. A. Mastrianni Amyotrophy in Prion Diseases Arch Neurol, January 1, 2000; 57(1): 33 - 38. [Abstract] [Full Text] [PDF]

				S. E Arnold, J. Q Trojanowski, and P. Parchi Protease resistant prion proteins are not present in sporadic "poor outcome" schizophrenia J. Neurol. Neurosurg. Psychiatry, January 1, 1999; 66(1): 90 - 92. [Abstract] [Full Text]

				P. Parchi, S. G. Chen, P. Brown, W. Zou, S. Capellari, H. Budka, J. Hainfellner, P. F. Reyes, G. T. Golden, J. J. Hauw, et al. Different patterns of truncated prion protein fragments correlate with distinct phenotypes in P102L Gerstmann-Straussler-Scheinker disease PNAS, July 7, 1998; 95(14): 8322 - 8327. [Abstract] [Full Text] [PDF]

				A. K. Shetty and R. W. Steele Commentary Review: Prion Diseases Clinical Pediatrics, January 1, 1997; 36(1): 1 - 7. [PDF]