| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Austin and Repatriation Medical Centre (Dr. Cher), Melbourne, Australia; New York University Medical Center (Dr. Glass), New York, NY; and Massachusetts General Hospital (Drs. Harsh and Hochberg), Boston, MA.
Presented in part at the 46th annual meeting of the American Academy of Neurology, Washington, DC, May 5, 1994.
Received June 5, 1995. Accepted in final form October 10, 1995.
Address correspondence and reprint requests to Dr. Jon Glass, 530 First Avenue, Suite 9S, New York, NY 10016.
Disease-free survival in primary CNS lymphoma has improved with the advent of methotrexate-based pre-irradiation chemotherapy. Prolonged response durations have been noted in six of eight patients refusing radiation therapy in two of our prior series. We have treated an additional 11 patients with methotrexate-based chemotherapy without subsequent planned irradiation. Some received maintenance chemotherapy. Most have had durable responses with little or no toxicity. Prolonged responses can be maintained without radiation therapy, thus avoiding potential long-term radiation toxicity.
NEUROLOGY 1996;46: 1757-1759
This article has been cited by other articles:
|
|
 |
|
  J.-J. Zhu, E. R. Gerstner, D. A. Engler, M. M. Mrugala, W. Nugent, K. Nierenberg, F. H. Hochberg, R. A. Betensky, and T. T. Batchelor High-dose methotrexate for elderly patients with primary CNS lymphoma Neuro-oncol, January 1, 2009; 11(2): 211 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Yamanaka, K. Morii, Y. Shinbo, J. Homma, M. Sano, N. Tsuchiya, N. Yajima, T. Tamura, H. Hondoh, H. Takahashi, et al. Results of Treatment of 112 Cases of Primary CNS Lymphoma Jpn. J. Clin. Oncol., May 1, 2008; 38(5): 373 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Hottinger, L. M. DeAngelis, J. Yahalom, and L. E. Abrey Salvage whole brain radiotherapy for recurrent or refractory primary CNS lymphoma Neurology, September 11, 2007; 69(11): 1178 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Nguyen, A. Chakravarti, D. M. Finkelstein, F. H. Hochberg, T. T. Batchelor, and J. S. Loeffler Results of Whole-Brain Radiation As Salvage of Methotrexate Failure for Immunocompetent Patients With Primary CNS Lymphoma J. Clin. Oncol., March 1, 2005; 23(7): 1507 - 1513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M.P. Poortmans, H. C. Kluin-Nelemans, H. Haaxma-Reiche, M. Van't Veer, M. Hansen, P. Soubeyran, M. Taphoorn, J. Thomas, M. Van den Bent, M. Fickers, et al. High-Dose Methotrexate-Based Chemotherapy Followed by Consolidating Radiotherapy in Non-AIDS-Related Primary Central Nervous System Lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962 J. Clin. Oncol., December 15, 2003; 21(24): 4483 - 4488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J.M. Ferreri, L. E. Abrey, J.-Y. Blay, B. Borisch, J. Hochman, E. A. Neuwelt, J. Yahalom, E. Zucca, F. Cavalli, J. Armitage, et al. Summary Statement on Primary Central Nervous System Lymphomas From the Eighth International Conference on Malignant Lymphoma, Lugano, Switzerland, June 12 to 15, 2002 J. Clin. Oncol., June 15, 2003; 21(12): 2407 - 2414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Baehring, D. Damek, E. C. Martin, R. A. Betensky, and F. H. Hochberg Neurolymphomatosis Neuro-oncol, April 1, 2003; 5(2): 104 - 115. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Fliessbach, H. Urbach, C. Helmstaedter, H. Pels, A. Glasmacher, J. A. Kraus, T. Klockgether, I. Schmidt-Wolf, and U. Schlegel Cognitive Performance and Magnetic Resonance Imaging Findings After High-Dose Systemic and Intraventricular Chemotherapy for Primary Central Nervous System Lymphoma Arch Neurol, April 1, 2003; 60(4): 563 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Batchelor, K. Carson, A. O'Neill, S. A. Grossman, J. Alavi, P. New, F. Hochberg, and R. Priet Treatment of Primary CNS Lymphoma With Methotrexate and Deferred Radiotherapy: A Report of NABTT 96-07 J. Clin. Oncol., March 15, 2003; 21(6): 1044 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A multicenter study of treatment of primary CNS lymphoma Neurology, May 28, 2002; 58(10): 1513 - 1520.
|
|
|
|
|
|
E. M. Bessell, A. Lopez-Guillermo, S. Villa, E. Verger, B. Nomdedeu, J. Petit, P. Byrne, E. Montserrat, and F. Graus Importance of Radiotherapy in the Outcome of Patients With Primary CNS Lymphoma: An Analysis of the CHOD/BVAM Regimen Followed by Two Different Radiotherapy Treatments J. Clin. Oncol., January 1, 2002; 20(1): 231 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lister, L. E. Abrey, and J. T. Sandlund Central Nervous System Lymphoma Hematology, January 1, 2002; 2002(1): 283 - 296. [Abstract] [Full Text]
|
|
|
|
|
|
P. O’Brien, D. Roos, G. Pratt, K. Liew, M. Barton, M. Poulsen, I. Olver, and G. Trotter Phase II Multicenter Study of Brief Single-Agent Methotrexate Followed by Irradiation in Primary CNS Lymphoma J. Clin. Oncol., February 1, 2000; 18(3): 519 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ng, M. A. Rosenthal, D. Ashley, and L. Cher High-dose methotrexate for primary CNS lymphoma in the elderly Neuro-oncol, January 1, 2000; 2(1): 40 - 44. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Aghi, C. M. Kramm, and X. O. Breakefield Folylpolyglutamyl Synthetase Gene Transfer and Glioma Antifolate Sensitivity in Culture and In Vivo J Natl Cancer Inst, July 21, 1999; 91(14): 1233 - 1241. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
