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From the Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA.
Supported in part by funding from the U.S. Public Health Services (AG09399 and DC00039) and the Charles A. Dana Foundation.
Presented in part at the Academy of Aphasia, Boston, October 1994.
Received July 17, 1995. Accepted in final form November 27, 1995.
Address correspondence and reprint requests to Dr. Murray Grossman, Cognitive Neurology Section, Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283.
We studied 20 patients with Alzheimer's disease (AD) on a picture-naming task consisting of frequency-matched pairs of nouns and verbs that were homophonic and homographic (e.g., paint). Intragroup comparisons revealed that verb naming is significantly more difficult for patients with AD than noun naming. An error analysis demonstrated that patients with AD produce significantly more semantic and descriptive errors for verbs than nouns. We correlated verb naming and noun naming with measures of grammatical comprehension, lexical retrieval, and visuoperceptual processing, but there were no selective effects for verbs compared with nouns. Differences in the mental representation of concepts underlying verbs and nouns may account, in part, for the relative difficulty naming with verbs in AD.
NEUROLOGY 1996;47: 178-182
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