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NEUROLOGY 1996;47:18-21
© 1996 American Academy of Neurology

Axonal channelopathies

An evolving concept in the pathogenesis of peripheral nerve disorders Ludwig Gutmann, MD and Laurie Gutmann, MD

From the Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV.
Received October 10, 1995. Accepted in final form January 10, 1996.
Address correspondence and reprint requests to Dr. Ludwig Gutmann, Department of Neurology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506-9180.

Abnormalities of peripheral nerve Na sup + and K sup + channels result in clinical manifestions unrelated to axonal degeneration or demyelination.Na sup + channel blockade causes weakness and sensory loss associated with slowed conduction and decreased motor and sensory action potential amplitudes. K sup + channel abnormalities result in high frequency repetitive action potentials (e.g., myokymia). Ion channel abnormalities may also play an important role in electrophysiologic changes seen in demyelinating disorders.

NEUROLOGY 1996;47: 18-21




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