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NEUROLOGY 1996;47:254-256
© 1996 American Academy of Neurology

Increased risk of dementia in mothers of Alzheimer's disease cases

Evidence for maternal inheritance

S. D. Edland, MS, J. M. Silverman, PhD, E. R. Peskind, MD, D. Tsuang, MD, E. Wijsman, PhD and J. C. Morris, MD

From the Departments of Environmental Health and Biostatistics (Dr. Edland), the Puget Sound Veteran's Health Care System and Department of Psychiatry and Behavioral Science (Drs. Peskind and Tsuang); the Departments of Medicine and Biostatistics (Dr. Wijsman), University of Washington, Seattle, WA; the Department of Psychiatry (Dr. Silverman), Mount Sinai School of Medicine, New York, NY; and the Department of Neurology (Dr. Morris), Washington University, St. Louis, MO.
Supported in part by NIA grant AG06790 and AG05136.
Received and accepted in final form December 29, 1995.
Address correspondence and reprint requests to Dr. Steven D. Edland, University of Washington, 4225 Roosevelt Way, NE, Suite 301, Seattle, WA 98105.

This study tests the hypothesis of maternal inheritance of AD in families of 118 subjects with this disorder enrolled in The Consortium to Establish a Registry for Alzheimer's Disease (CERAD).The parental generation included 24 subjects with dementia. Using the Cox proportional hazards model, we found the age-adjusted mother-to-father relative risk to be 2.8 (95% CI, 1.1 to 7.7). Among a subset of 10 families with one affected parent and at least two affected siblings, the ratio of affected mothers-to-fathers was 9:1. These findings support recent studies that found a high mother-to-father ratio among affected parents of subjects with AD. Together, these results suggest maternal inheritance of AD and are consistent with several hypotheses regarding the genetic nature of AD.

NEUROLOGY 1996;47: 254-256




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