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From the Gertrude H. Sergievsky Center (Drs. Ramachandran, Marder, Tang, Schofield, Chun, Stern, and Mayeux), the Division of Epidemiology in the Columbia University School of Public Health (Drs. Tang and Mayeux), the Center for Alzheimer's Disease Research in the City of New York (Drs. Stern and Mayeux), and the Departments of Neurology (Drs. Ramachandran, Marder, Schofield, Chun, Stern, and Mayeux), and Psychiatry (Drs. Devanand, Stern, and Mayeux) of the College of Physicians and Surgeons at Columbia University, New York, NY.
Dr. Ramachandran is now with the Departments of Psychiatry and Neurology of the State University of New York at Stony Brook and the Long Island Alzheimer's Disease Assistance Center, Stony Brook, NY.
Supported by Federal Grants AG07232, AG10963, AG08702, and RR00645 and from the Charles S. Robertson Memorial Gift for Alzheimer's Disease Research from the Banbury Fund.
Received March 23, 1995. Accepted in final form January 2, 1996.
Address correspondence and reprint requests to Dr. Richard Mayeux, G.H. Sergievsky Center, 630 West 168th Street, New York, NY 10032.
We evaluated the frequency of depression and psychosis in 46 patients with AD and 135 control subjects with the apolipoprotein (APO) E3/3 or E3/4 genotype.Patients with AD and the APOE3/4 genotype had a more than threefold increase in the signs of depression and psychosis when compared with either patients with the APOE3/3 genotype or to control subjects. Our preliminary study suggests that the phenotype of AD associated with the epsilon 4 allele is more likely to include psychiatric manifestations.
NEUROLOGY 1996;47: 256-259
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