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NEUROLOGY 1996;47:12S-16S
© 1996 American Academy of Neurology

Treatment with antiepileptic drugs

Possible neuroprotective effects

Asla Pitkanen, MD, PhD

From the A.I. Virtanen Institute and the Department of Neurology, the University of Kuopio, Kuopio, Finland.
Address correspondence and reprint requests to Dr. Asla Pitkanen, University of Kuopio, A.I. Virtanen Institute, P.O. Box 1627, FIN-70 211 Kuopio, Finland.

Abstract.

Findings from studies involving both rat models of epilepsy and humans with temporal lobe epilepsy suggest that epileptic seizures may induce hippocampal neuronal damage.This damage appears to be progressive over time and has been shown to be associated with memory impairment. Vigabatrin has been shown to protect against hippocampal neuronal cell death in experimental models of epilepsy. Because of the protection it provides against neuronal loss and functional impairment, vigabatrin may be a useful component of antiepileptic polytherapy.

NEUROLOGY 1996;47(Suppl 1): S12-S16






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