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NEUROLOGY 1996;47:6S-11S
© 1996 American Academy of Neurology

Cognitive effects of vigabatrin

A review

Francesco Monaco, MD

From the Clinica Neurologica, University of Sassari and Torino, Torino, Italy.
Address correspondence and reprint requests to Professor Francesco Monaco, Clinica Neurologica, Via Cherasco 15, 10126 Torino, Italy.

Abstract.

Studies were reviewed in which patients who received vigabatrin underwent cognitive testing.The overall results were categorized into five areas of cognitive function: reception, attention, intellectual function, memory, and psychomotor function. Overall, the studies showed either no detrimental effects or, in some cases, slightly improved function. It is speculated that a relationship exists between GABA and the results of these studies because vigabatrin enhances the GABAergic mechanism in the CNS.

NEUROLOGY 1996;47(Suppl 1): S6-S11






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