HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by van der Grond, J. Articles by Mali, W. P.Th.M. Search for Related Content PubMed PubMed Citation Articles by van der Grond, J. Articles by Mali, W. P.Th.M.

Cerebral metabolic differences between the severe and critical hypoperfused brain

From the Departments of Radiology (Drs. van der Grond, Ramos, and Mali) and Vascular Surgery (Dr. Eikelboom), University Hospital Utrecht, Utrecht, The Netherlands.
Supported by the Dutch Heart Foundation, grant no. D94.012.
Received September 26, 1995. Accepted in final form January 26, 1996.
Address correspondence and reprint requests to Dr. J. van der Grond, Department of Radiology, University Hospital Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.

Occlusion or severe stenosis, with a reduction in the diameter of the extracranial arteries of more than 70%, may lead to hypoperfusion of the brain with an increased risk of cerebral infarction.The aim of this study was to investigate whether a decrease in metabolism in noninfarcted hypoperfused cerebral areas is correlated with the level of hypoperfusion. Fifty-one patients without infarcts, with borderzone infarcts, with territory infarcts, and fourteen healthy control subjects were investigated with MRI and MR spectroscopic imaging. The NAA/choline ratio in the symptomatic hemisphere was significantly decreased in patients with borderzone infarcts compared with patients without infarcts, with patients with territory infarcts, and with control subjects. Furthermore, patients with borderzone infarcts had a relatively high frequency of cerebral lactate. These results indicate that there might be a lower limit of hypoperfusion that can be measured indirectly with MR spectroscopic imaging, below which irreversible cerebral damage occurs.

NEUROLOGY 1996;47: 399-404

This article has been cited by other articles:

				D Lythgoe, A Simmons, A Pereira, M Cullinane, S Williams, and H S Markus Magnetic resonance markers of ischaemia: their correlation with vasodilatory reserve in patients with carotid artery stenosis and occlusion J. Neurol. Neurosurg. Psychiatry, July 1, 2001; 71(1): 58 - 62. [Abstract] [Full Text] [PDF]

				P. M. Rothwell and C. P. Warlow Low Risk of Ischemic Stroke in Patients With Reduced Internal Carotid Artery Lumen Diameter Distal to Severe Symptomatic Carotid Stenosis : Cerebral Protection Due to Low Poststenotic Flow? Stroke, March 1, 2000; 31(3): 622 - 630. [Abstract] [Full Text] [PDF]

				K. J. van Everdingen, C. J. M. Klijn, L. J. Kappelle, W. P. T. M. Mali, and J. van der Grond MRA Flow Quantification in Patients With a Symptomatic Internal Carotid Artery Occlusion Stroke, August 1, 1997; 28(8): 1595 - 1600. [Abstract] [Full Text]