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Headache in ambulatory HIV-1-infected men enrolled in a longitudinal study

From the Neurology and Research Services, DVA West Los Angeles Medical Center and the Department of Neurology, UCLA School of Medicine, Los Angeles, CA.
Supported in part by the National Institutes of Mental Health (MH47281 RO1); the Veterans Health Service and Research Administration, Department of Veteran Affairs; the Neurologic AIDS Research Consortium (IP0INS32228-01); and the AIDS Regional Education and Training Center (5D35 PE 00106).
Received April 28, 1995. Accepted in final form December 1, 1995.
Address correspondence and reprint requests to Dr. Elyse J. Singer, Neurology Service (W127), DVA West Los Angeles Medical Center, 11301 Wilshire Blvd., Los Angeles, CA 90073.

Objective: To report headache (HA) data collected from subjects in a longitudinal study of human immunodeficiency virus (HIV)-1 and the central nervous system (CNS). Design/methods: Baseline data from 229 ambulatory HIV-seropositive (HIV+) and 53 seronegative control subjects were analyzed. Subjects were classified by the presence or absence of HIV-1-associated HAs and HIV-1-associated systemic and neurologic disease. Subjects were followed longitudinally for up to 5 years. Results: In the cross-sectional analysis, significant associations were observed between HIV-1-associated HAs and (1) anxiety and depression, and (2) a history of drug use, psychiatric disease, and non-HIV-1 neurologic disease. No significant differences in laboratory values were found between subjects with HIV-1-associated HA compared with those without HA. When HIV+ subjects were followed longitudinally, onset of new HIV-1-associated systemic or neurologic disease over 1 year was not predicted by the presence of an HIV-1-associated HA at baseline. Conclusion: Headaches are common in HIV+ persons at all stages of disease. Presence of HIV-1-associated HAs at baseline were not associated with neurologic disease progression over 1 year of follow-up in our sample.

NEUROLOGY 1996;47: 487-494

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