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Further evidence on the link between migraine and neuroticism

From the Department of Psychiatry (Drs. Breslau and Chilcoat, and P. Andreski), Henry Ford Health Sciences Center, Detroit, MI; the Department of Psychiatry (Dr. Breslau), Case Western University, School of Medicine, Cleveland, OH; and the Department of Psychiatry (Dr. Breslau), University of Michigan, School of Medicine, Ann Arbor, MI.
Supported by grant MH-48802 and P50 MS 32399 from the National Institutes of Health, Bethesda, MD.
Received January 22, 1996. Accepted in final form March 6, 1996.
Address correspondence and reprint requests to Dr. Naomi Breslau, Department of Psychiatry, Henry Ford Health Sciences Center, 1 Ford Place, 3A, Detroit, MI 48202-3450.

Epidemiologic studies have demonstrated an association between migraine and neuroticism.In this report, we examine prospectively whether higher levels of neuroticism, measured at baseline by the Eysenck Personality Questionnaire, signaled increased risk for first incidence of migraine during a 5-year follow-up interval. The sample was randomly selected from the list of young adult members of a large Health Maintenance Organization in southeast Michigan. Follow-up data were available on 972 subjects, 97.2% of the initial sample. Neuroticism predicted the first incidence of migraine in females. The relative risk for migraine in females scoring in the highest quartile of the neuroticism scales versus the lowest quartile was 4.0 (95% Cl 1.6, 10.3). Controlling for history of major depression and anxiety disorders at baseline reduced the estimate to 2.9 (95% Cl 1.1, 7.7). Neuroticism did not predict migraine in males, although the results in males were limited greatly by the small number of incidence cases. Neuroticism might be causally related to migraine, or alternatively, might be an early correlate with shared etiologies.

NEUROLOGY 1996;47: 663-667

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