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From the Departments of Neurology (Dr. Golomb), Psychiatry (Drs. Kluger, de Leon, Ferris, and Mittelman), and Radiology (Dr. George), Aging and Dementia Research Center, New York University Medical Center, and the Department of Psychology (Dr. Cohen), Graduate School of Arts and Science, New York University, New York, NY.
Supported in part by grants 1R01AG12101, 1R01AG03051, 1P30AG08051, and 1R29MH44697 from the National Institutes of Health.
Received November 27, 1995. Accepted in final form January 22, 1996.
Address correspondence and reprints requests to Dr. J. Golomb, Aging and Dementia Research Center, New York University Medical Center, HN-314, Tisch Hospital, 550 First Avenue, New York, NY 10016.
Hippocampal formation (HF) atrophy, although common in normal aging, has unknown clinical consequences.We used MRI to derive HF size measurements at baseline on 44 cognitively normal older adults entering a longitudinal study of memory function (mean age = 68.4 years, mean follow-up = 3.8 years). Only one subject became demented at follow-up. Multiple regression analyses controlling for age, gender, education, and diffuse cerebral atrophy revealed that HF size significantly predicted longitudinal change on memory tests previously found sensitive to decline in normal aging. These results indicate HF atrophy may be a risk factor for accelerated memory dysfunction in normal aging.
NEUROLOGY 1996;47: 810-813
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