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T-cell receptor alpha, beta, gamma, and delta chain gene microsatellites show no association with multiple sclerosis

From the Department of Neurology (Drs. Droogan and Hawkins), Royal Victoria Hospital, Belfast; Regional Genetics Centre (Miss Kirk, and Drs. Graham and Nevin), Belfast City Hospital; and the Regional Immunology Service (Dr. McMillan), Belfast City Hospital, Belfast, Northern Ireland.
Supported by a grant from The Multiple Sclerosis Society of Great Britain and Northern Ireland.
Received October 18, 1995. Accepted in final form January 31, 1996.
Address correspondence and reprint requests to Dr. Colin A. Graham, Regional Genetics Centre, Tower, Floor A, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland.

Genetic predisposition to multiple sclerosis (MS) is determined, in part, by certain HLA genotypes, but the contribution of T-cell receptor (TCR) germline polymorphisms to MS susceptibility is less clear. Reports of disease associations with restriction fragment length polymorphisms of TCR alpha and beta chain genes have been difficult to confirm, and little data is available on the influence of the TCR gamma delta germline in MS. We investigated the TCR alpha, beta, gamma, and delta chain genes of Northern Irish patients with MS using four microsatellite markers of high heterozygosity. There were similar allele frequencies in patients and controls for all microsatellites studied. We conclude there is no convincing evidence for an association of MS with TCR alpha, beta, gamma, and delta chain gene polymorphisms.

NEUROLOGY 1996;47: 1049-1053

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