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From the G.H. Sergievsky Center and Epidemiology Division (Dr. Ottman), School of Public Health, Columbia University, and Epidemiology of Brain Disorders Department, New York State Psychiatric Institute, New York; and the Departments of Neurology, and Epidemiology and Social Medicine (Dr. Lipton), Albert Einstein College of Medicine, and Montefiore Headache Unit, Montefiore Medical Center, New York, NY.
Supported by NIH grant RO1-NS20656 and a research grant from Abbott Pharmaceuticals.
Received November 17, 1995. Accepted in final form January 24, 1996.
Address correspondence and reprint requests to Dr. Ruth Ottman, G.H. Sergievsky Center, Columbia University, 630 W. 168th Street, New York, NY 10032.
We tested the hypothesis that the comorbidity of migraine and epilepsy results from a shared genetic susceptibility to the two disorders.We used semistructured telephone interviews to collect information on migraine and epilepsy in the families (parents, siblings, and offspring) of 1,957 adult probands with epilepsy. Epilepsy was defined as a lifetime history of two or more unprovoked seizures, and migraine as self-reported severe headaches with two or more of the following symptoms: unilateral pain, throbbing pain, visual aura, or nausea. As a first test of the hypothesis of shared susceptibility, we assessed risk of migraine in relatives of probands with genetic versus nongenetic forms of epilepsy, using two proxy measures of genetic susceptibility--a first-degree family history of epilepsy and idiopathic/cryptogenic (versus postnatal symptomatic) etiology. Neither of these two measures was associated with risk of migraine in relatives. As a second test, we assessed risk of epilepsy in the relatives of probands with versus without migraine. With the exception of one subgroup (sons of female probands), risk of epilepsy in relatives was not associated with the proband's history of migraine. This pattern of results is inconsistent with the hypothesis of a shared genetic susceptibility to migraine and epilepsy.
NEUROLOGY 1996;47: 918-924
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