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From the Departments of Neurology (Drs. Klatka and Schiffer) and Psychiatry (Dr. Schiffer), University of Rochester Medical Center, Rochester, NY; Department of Neurology (Dr. Klatka), Walter Reed Army Medical Center, Washington, DC; Department of Neurology and G. Sergievsky Center (Dr. Louis), Columbia University, College of Physicians and Surgeons, New York, NY.
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
Supported by grants from the Training in Geriatrics and Neurobiology of Aging (T32AG00107-11), the Rochester Alzheimer's Disease Center (P30AG08665), and Genetic Epidemiology of Essential Tremor (NIH NS010863).
Received January 30, 1996. Accepted in final form May 30, 1996.
Address correspondence and reprint requests to Dr. Lisa A. Klatka, Neurology Clinic, Ward 62, Walter Reed Army Medical Center, 6825 Georgia Ave., N.W., Washington, DC 20307.
We conducted a retrospective study to determine the frequency of depression, hallucinations, and delusions in patients with diffuse Lewy body disease (DLBD) and to compare these findings with those in Alzheimer's disease (AD) and Parkinson's disease (PD).One hundred twelve subjects were included in the study. Of these, 28 subjects were diagnosed with DLBD, 58 with AD, and 26 with PD at autopsy. Main outcome measures included the percentages of subjects in each of the three categories in whom depression, hallucinations, or delusions were reported at any time during the course of the illness. Hallucinations and delusions were further classified by type. We found that depression was more common in DLBD (50.0%) than in AD (13.8%) (chi squared = 13.00, p = 0.0003). There was no difference in the frequency of depression in DLBD and PD (57.7%) (chi squared = 0.32, p = 0.57). Hallucinations were reported more frequently in DLBD (60.7%) than in AD (34.5%) (chi squared = 5.30, p = 0.021). There was no difference in the frequency of hallucinations in DLBD and PD (53.8%) (chi squared = 0.26, p = 0.61). Delusions were more common in DLBD (57.1%) than in PD (15.4%) (chi squared = 10.08, p = 0.0015). There was no difference in the frequency of delusions in DLBD and AD (53.4%) (chi squared = 0.10, p = 0.75). There was a male predominance of DLBD cases and PD cases; AD cases were predominantly women. We conclude that psychiatric features are very common in DLBD and should be a central diagnostic criterion for the disease.
NEUROLOGY 1996;47: 1148-1152
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