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From the Neuroepidemiology Branch (Dr. Litvan), National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; the Departments of Neurology (Drs. Mega, Cummings, and Fairbanks), and Psychiatry and Biobehavioral Science (Dr. Cummings), UCLA School of Medicine; and the Behavioral Neuroscience Section (Drs. Mega and Cummings), Psychiatry Service, West Los Angeles Veterans Affairs Medical Center, Los Angeles, CA.
Supported by the Department of Veteran Affairs, NIA Alzheimer Disease Center grant (AG10123) and the Irving and Helga Cooper Award of the UCLA Center on Aging.
Received February 16, 1996. Accepted in final form March 20, 1996.
Address correspondence and reprint requests to Dr. Irene Litvan, Neuroepidemiology Branch, NINDS, NIH, Federal Bldg., Room 714, Bethesda, MD 20892-9130.
Administering the Neuropsychiatric Inventory (NPI), we examined the behavioral symptoms of 22 patients with progressive supranuclear palsy (PSP), 50 patients with Alzheimer's disease, and 40 controls.PSP patients exhibited apathy (91%), disinhibition (36%), dysphoria (18%) and anxiety (18%), but rarely (<9%) irritability, abnormal motor behaviors, or agitation. Apathy in PSP was significantly associated with executive dysfunction. The presence of high apathy and low agitation and anxiety scale scores correctly identified the PSP patients 85% of the time. Evaluating the behavioral abnormalities of patients with neurodegenerative disorders will aid diagnosis and facilitate management.
NEUROLOGY 1996;47: 1184-1189
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