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Excitotoxicity in ALS

From the Department of Clinical Neurosciences, Institute of Psychiatry, London, UK.
Professor Leigh's research is supported by grants from the Medical Research Council, The Wellcome Trust, and the Motor Neuron Disease Association. The Institute of Psychiatry (P.N.L.) has received funding from Rhone-Poulenc Rorer for the conduct of the Riluzole 301 trial and from Cephalon Inc. for the conduct of the 1202 trial of myotrophin.
Address correspondence and reprint requests to Professor P.N. Leigh, Department of Clinical Neurosciences, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK.

Abstract.

This review will summarize current understanding of the molecular and cellular mechanisms of excitotoxicity, the organization of glutamate systems in relation to ALS and evidence that excitotoxicity is relevant to the pathogenesis of ALS.

NEUROLOGY 1996;47(Suppl 4): S221-S227