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NEUROLOGY 1997;48:614-620
© 1997 American Academy of Neurology

Alcohol use is a risk factor for a first generalized tonic-clonic seizure

M. Leone, MD, E. Bottacchi, MD, E. Beghi, MD, E. Morgando, MD, R. Mutani, MD, G. Amedeo, MD, R. Cremo, MD, M. Gianelli, MD and L. Ravagli Ceroni, MSc

The ALC.E., (Alcohol and Epilepsy) Study Group*.
*See page 619 for ALC.E. Study Group members.
From Divisione Universitaria di Neurologia (Drs. Leone, Mutani, and Gianelli), Facolta di Medicina e Chirurgia di Novara, Universita di Torino; U.O. di Neurologia e Neurofisiopatologia (Dr. Bottacchi), Ospedale Regionale, Aosta; Laboratorio di Farmacologia Clinica, Istituto di Ricerche Farmacologiche "Mario Negri", Milano, and Clinica Neurologica, Ospedale S. Gerardo, Monza (Dr. Beghi); DEA di Neurologia (Drs. Morgando, Amedeo, and Cremo), Ospedale Molinette, Torino; Assessorato della Sanita (Dr. Ravagli Ceroni), Regione Valle d'Aosta; The ALC.E. (Alcohol and Epilepsy) Study Group.
Supported in part by the "Assessorato della Sanita della Regione Valle d'Aosta."
Presented in part at the 46th annual meeting of the American Academy of Neurology, Washington, DC, May 1994.
Received April 19, 1996. Accepted in final form August 30, 1996.
Address correspondence and reprint requests to Dr. Maurizio Leone, Divisione Universitaria di Neurologia, Ospedale Maggiore, C. Mazzini 18, 28100 Novara, Italy.

Article abstract-We performed a multicenter case-control study to estimate whether chronic alcoholism and alcohol consumption are risk factors for developing a first generalized tonic-clonic seizure (GTCS). We studied 237 first-seizure patients (158 men, 79 women) matched to 474 hospital controls for center, sex, age (+/- 5 years), and weekday of the seizure. The risk of first GTCS in alcoholics was greater than in non-alcoholics for men (odds ratio, 6.8; 95% confidence limits, 3.6-13.0) and women (6.8, 1.6-32.6). The odds ratio (both sexes) was 1.2 (0.8-1.8) for an average daily intake of absolute alcohol of 1 to 25 g/day and rose with the amount of alcohol consumed daily: 1.3 (0.8-2.1) for 26 to 50 g/day, 3.0 (1.7-5.4) for 51 to 100 g/day, 7.9 (2.9-21.9) for 101 to 200 g/day, and 16.6 (1.9-373.4) for >200 g/day. Our study provides evidence of a powerful association between alcohol use, alcoholism, and the first GTCS.

NEUROLOGY 1997;48: 614-620




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 J. Neurol. Neurosurg. PsychiatryHome page
M Leone, C Tonini, G Bogliun, F Monaco, R Mutani, E Bottacchi, P Gambaro, E Rocci, T Tassinari, C Cavestro, et al.
Chronic alcohol use and first symptomatic epileptic seizures
J. Neurol. Neurosurg. Psychiatry, November 1, 2002; 73(5): 495 - 499.
[Abstract] [Full Text] [PDF]


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