Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Friedman, J. H.
Right arrow Articles by Smith, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Friedman, J. H.
Right arrow Articles by Smith, D.

Neurology, Vol 48, Issue 4 1077-1081, Copyright © 1997 by American Academy of Neurology

ARTICLES

Benztropine versus clozapine for the treatment of tremor in Parkinson's disease

JH Friedman, WC Koller, MC Lannon, K Busenbark, E Swanson-Hyland and D Smith
Memorial Hospital of Rhode Island, Department of Clinical Neurosciences, Pawtucket 02860, USA.

Four open-label studies have reported beneficial effects of clozapine on the tremor of idiopathic Parkinson's disease (PD). We performed a double-blind crossover trial with a 2-week washout, comparing low-dose clozapine to benztropine for the treatment of tremor in PD. Twenty-two subjects enrolled and 19 completed the study. Benztropine and clozapine were equally effective in improving tremor and the motor score of the United Parkinson's Disease Rating Scale at mean doses of 3.0 and 39 mg/day, respectively. Significant adverse events were experienced with each drug, but leukopenia was not encountered. We conclude that the atypical antipsychotic drug clozapine is helpful in the treatment of tremor in PD and should be considered when all other drug therapies fail.


This article has been cited by other articles:


Home page
 BrainHome page
M. M. Sturman, D. E. Vaillancourt, L. V. Metman, R. A. E. Bakay, and D. M. Corcos
Effects of subthalamic nucleus stimulation and medication on resting and postural tremor in Parkinson's disease
Brain, September 1, 2004; 127(9): 2131 - 2143.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. Jankovic
Levodopa strengths and weaknesses
Neurology, February 1, 2002; 58(90001): S19 - 32.
[Abstract] [Full Text]

Home page
 NeurologyHome page
R. J. Elble
Tremor and dopamine agonists
Neurology, February 1, 2002; 58(90001): S57 - 62.
[Abstract] [Full Text]

Home page
 NeurologyHome page
C. W. Olanow, R. L. Watts, and W. C. Koller
An algorithm (decision tree) for the management of Parkinson's disease (2001):: Treatment
Neurology, June 12, 2001; 56(suppl_5): S1 - S88.
[Full Text] [PDF]

Home page
 Arch Intern MedHome page
Habib-ur-Rehman
Diagnosis and Management of Tremor
Arch Intern Med, September 11, 2000; 160(16): 2438 - 2444.
[Abstract] [Full Text]

Home page
 NEJMHome page
The Parkinson Study Group
Low-Dose Clozapine for the Treatment of Drug-Induced Psychosis in Parkinson's Disease
N. Engl. J. Med., March 11, 1999; 340(10): 757 - 763.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. E. Lang and A. M. Lozano
Parkinson's Disease- Second of Two Parts
N. Engl. J. Med., October 15, 1998; 339(16): 1130 - 1143.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by AAN Enterprises, Inc.