Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Malandrini, A.
Right arrow Articles by Guazzi, G. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Malandrini, A.
Right arrow Articles by Guazzi, G. C.
NEUROLOGY 1997;48:1200-1203
© 1997 American Academy of Neurology

Unusual clinical features and early brain MRI lesions in a family with cerebral autosomal dominant arteriopathy

A. Malandrini, MD, P. Carrera, PhD, G. Ciacci, MD, S. Gonnelli, MD, M. Villanova, MD, S. Palmeri, MD, L. Vismara, MD, V. Brancolini, PhD, E. Signorini, MD, M. Ferrari, MD and G. C. Guazzi, MD

From the Istituto Scienze Neurologiche (Drs. Malandrini, Ciacci, Villanova, Palmeri, and Guazzi), Università di Siena, Siena; Laboratorio di Genetica Molecolare (Drs. Carrera, Vismara, and Ferrari), IRCCS Ospedale S. Raffaele, Milano; Istituto di Patologia Medica (Dr. Gonnelli), Università di Siena, Siena; and Istituto di Radiologia "A. Cesalpino" (Dr. Signorini), Terontola, Italy; and Department of Psychiatry (Dr. Brancolini), Columbia University, New York, NY.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a recently described inherited disorder. The pathologic gene maps on chromosome 19. The clinical spectrum of the disease consists of recurrent strokes, migraine, transient ischemic attacks, mood changes, and dementia. We report a genetically assessed CADASIL family with atypical clinical presentations of epileptic seizures. In two asymptomatic family members there were early brain abnormalities on MRI. Our report expands the clinical spectrum of CADASIL and suggests that it is possibly an undiagnosed disorder.




This article has been cited by other articles:


Home page
 StrokeHome page
H. Reddy, N. De Stefano, M. Mortilla, A. Federico, and P. M. Matthews
Functional Reorganization of Motor Cortex Increases With Greater Axonal Injury From CADASIL
Stroke, February 1, 2002; 33(2): 502 - 508.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Hassan and H. S. Markus
Genetics and ischaemic stroke
Brain, September 1, 2000; 123(9): 1784 - 1812.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
D. W. Desmond, J. T. Moroney, T. Lynch, S. Chan, S. S. Chin, and J. P. Mohr
The Natural History of CADASIL : A Pooled Analysis of Previously Published Cases
Stroke, June 1, 1999; 30(6): 1230 - 1233.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by AAN Enterprises, Inc.