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NEUROLOGY 1997;48:35S-41S
© 1997 American Academy of Neurology

The search for disease-modifying treatment for Alzheimer's disease

Paul S. Aisen, MD and Kenneth L. Davis, MD

From the Department of Psychiatry, Mount Sinai School of Medicine, New York, NY.
Address correspondence and reprint requests to Dr. Paul S. Aisen, Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029.

Abstract.

Article abstract-As a result of advances in the understanding of neurodegenerative mechanisms in Alzheimer's disease, several strategies for the development of disease-modifying treatment are being investigated. Nerve growth factor and other neurotrophins may improve neuronal survival, although targeted delivery remains an obstacle. Modulation of protein processing has the potential to decrease the formation of plaques and tangles. Pharmacologic reduction of oxidative stress and destructive inflammation may slow the rate of neurodegeneration. Continued research into basic mechanisms, along with therapeutic trials of promising drugs, are improving the likelihood that it will soon be possible to slow the progression of this disease.

NEUROLOGY 1997;48(Suppl 6): S35-S41




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American Journal of Alzheimer's Disease and Other Dementias, May 1, 2008; 23(2): 150 - 161.
[Abstract] [PDF]


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